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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-31
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pubmed:abstractText |
Increasing evidence suggests that a genetically determined functional impairment of the hepatocellular efflux transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein 3 (MDR3, ABCB4) play a pathophysiological role in the development of drug-induced liver injury. The aim of this study was therefore to describe the extent of genetic variability in ABCB11 and ABCB4 in patients with drug-induced liver injury and to in vitro functionally characterize newly detected ABCB11 mutations and polymorphisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1744-6872
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-60
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17264802-ATP-Binding Cassette Transporters,
pubmed-meshheading:17264802-Adolescent,
pubmed-meshheading:17264802-Adult,
pubmed-meshheading:17264802-Aged,
pubmed-meshheading:17264802-Aged, 80 and over,
pubmed-meshheading:17264802-Amino Acid Sequence,
pubmed-meshheading:17264802-Cholestasis,
pubmed-meshheading:17264802-Drug-Induced Liver Injury,
pubmed-meshheading:17264802-European Continental Ancestry Group,
pubmed-meshheading:17264802-Female,
pubmed-meshheading:17264802-Genetic Predisposition to Disease,
pubmed-meshheading:17264802-Humans,
pubmed-meshheading:17264802-Liver Diseases,
pubmed-meshheading:17264802-Male,
pubmed-meshheading:17264802-Middle Aged,
pubmed-meshheading:17264802-Molecular Sequence Data,
pubmed-meshheading:17264802-Mutation,
pubmed-meshheading:17264802-P-Glycoproteins,
pubmed-meshheading:17264802-Polymorphism, Genetic,
pubmed-meshheading:17264802-Protein Structure, Secondary,
pubmed-meshheading:17264802-Taurocholic Acid
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pubmed:year |
2007
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pubmed:articleTitle |
Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.
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pubmed:affiliation |
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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