Linked Life Data

17262994

Source:http://linkedlifedata.com/resource/pubmed/id/17262994

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-1-31
pubmed:abstractText
Brain and spinal cord atrophy measures are becoming standard in multiple sclerosis (MS) clinical trials, yet we know little about the underlying mechanisms resulting in atrophy, or the factors accounting for variable rates of atrophy in individuals and across the MS phenotype. We do not understand, as yet, why apparently effective treatment does or does not affect atrophy. Some limitations of this measure may be accounted for by complex structural and temporal factors that become active at the initiation of injury, but are not immediately expressed. Additional limitations include differential effects related to the focal versus diffuse pathology in MS, and variable expression of the pathology underlying atrophy, depending on location in central nervous system (CNS) tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1352-4585
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
679-87
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Brain atrophy in multiple sclerosis: what we know and would like to know.
pubmed:affiliation
Department of Radiology, University of Colorado Health Sciences Center, Campus Box A034, Denver, CO 80262, USA. jack.simon@uchsc.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't