|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2007-2-7
|
|
pubmed:abstractText |
Antagonists of growth hormone-releasing hormone (GHRH) are being developed for the treatment of various cancers. In this study, we investigated the effectiveness of treatment with GHRH antagonist JMR-132 alone and in combination with docetaxel chemotherapy in nude mice bearing MX-1 human breast cancers. Specific high-affinity binding sites for GHRH were found on MX-1 tumor membranes using ligand competition assays with (125)I-labeled GHRH antagonist JV-1-42. JMR-132 displaced radiolabeled JV-1-42 with an IC(50) of 0.14 nM, indicating a high affinity of JMR-132 to GHRH receptors. Treatment of nude mice bearing xenografts of MX-1 with JMR-132 at 10 microg per day s.c. for 22 days significantly (P < 0.05) inhibited tumor volume by 62.9% and tumor weight by 47.8%. Docetaxel given twice at a dose of 20 mg/kg i.p. significantly reduced tumor volume and weight by 74.1% and 58.6%, respectively. Combination treatment with JMR-132 (10 microg/day) and docetaxel (20 mg/kg i.p.) led to growth arrest of most tumors as shown by an inhibition of tumor volume and weight by 97.7% and 95.6%, respectively (P < 0.001). Because no vital cancer cells were detected in some of the excised tumors, a total regression of the tumors was achieved in some cases. Treatment with JMR-132 also strongly reduced the concentration of EGF receptors in MX-1 tumors. Our results demonstrate that GHRH antagonists might provide a therapy for breast cancer and could be combined with docetaxel chemotherapy to enhance the efficacy of treatment.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10022420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10226594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10611309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10653871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10741306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10817510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10830299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10845811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10935510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-10962031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11181655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11248153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11301370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11344219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11564700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11582590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11587553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11593058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11773624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-11919237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12108894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12111694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12126741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12186980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12220726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12364462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12365022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12538852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12602901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-12637460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-14555706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-14633721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-15362970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-15650840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-15661684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-15911866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-16322899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-16831025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-6668509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-7473836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-8523050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-9159156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-9184172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-9671770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261802-9828250
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
6
|
|
pubmed:volume |
104
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1943-6
|
|
pubmed:dateRevised |
2010-9-15
|
|
pubmed:meshHeading |
pubmed-meshheading:17261802-Animals,
pubmed-meshheading:17261802-Antineoplastic Agents,
pubmed-meshheading:17261802-Cell Line, Tumor,
pubmed-meshheading:17261802-Drug Synergism,
pubmed-meshheading:17261802-Drug Therapy, Combination,
pubmed-meshheading:17261802-Female,
pubmed-meshheading:17261802-Growth Hormone-Releasing Hormone,
pubmed-meshheading:17261802-Humans,
pubmed-meshheading:17261802-Mammary Neoplasms, Experimental,
pubmed-meshheading:17261802-Mice,
pubmed-meshheading:17261802-Mice, Nude,
pubmed-meshheading:17261802-Taxoids,
pubmed-meshheading:17261802-Transplantation, Heterologous
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Potentiation of mammary cancer inhibition by combination of antagonists of growth hormone-releasing hormone with docetaxel.
|
|
pubmed:affiliation |
Veterans Affairs Medical Center and Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
|
