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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-2-6
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pubmed:abstractText |
Embryonic stem cell (ESC)-derived cardiomyocytes are anticipated to serve as a useful source for future cell-based cardiovascular disease therapies. Research emphasis is currently focused on determining methods to direct the differentiation of ESCs to a large population of cardiomyocytes with high purity. To this aim, understanding the molecular mechanisms that control ESC-to-cardiomyocyte differentiation should play a critical role in the development of this methodology. The Wnt/beta-catenin signaling pathway has been implicated in both embryonic cardiac development and in vitro ESC differentiation into cardiomyocytes. Chibby is a recently identified nuclear protein that directly binds to beta-catenin and antagonizes its transcriptional activity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-10431240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-10601008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-10662781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-10704849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-10893270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-11042197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-11159911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-11330862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-11526122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-12176021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-12194849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-12668514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-12712206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-12719544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-12837243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-12874139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-14555707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-14581414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-15067007,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-15304656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-15364612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-15494369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-15541384,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-16943279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-1779832,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17261658-9065401
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
6
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
617-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17261658-Animals,
pubmed-meshheading:17261658-Carrier Proteins,
pubmed-meshheading:17261658-Cell Differentiation,
pubmed-meshheading:17261658-Cell Line,
pubmed-meshheading:17261658-Cell Line, Transformed,
pubmed-meshheading:17261658-Down-Regulation,
pubmed-meshheading:17261658-Embryonic Stem Cells,
pubmed-meshheading:17261658-Humans,
pubmed-meshheading:17261658-Mice,
pubmed-meshheading:17261658-Myocytes, Cardiac,
pubmed-meshheading:17261658-Nuclear Proteins,
pubmed-meshheading:17261658-Signal Transduction,
pubmed-meshheading:17261658-Wnt Proteins,
pubmed-meshheading:17261658-beta Catenin
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pubmed:year |
2007
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pubmed:articleTitle |
Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells.
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pubmed:affiliation |
Department of Pathology, University of Florida College of Medicine, Box 100275, Gainesville, FL 32610, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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