Linked Life Data

1725994

Source:http://linkedlifedata.com/resource/pubmed/id/1725994

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-6-18
pubmed:abstractText
Fluid secretion from rat submandibular saliva evoked by electrical stimulation of the chorda tympani (parasympathetic secretory stimulation) was greatly reduced in the presence of atropine. However, some secretion was always evident at frequencies of 5 Hz and higher. The substance P-antagonist ([D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P) also reduced the chorda-evoked saliva. Salivary secretion induced by the electrical stimulation of the superior cervical ganglion (sympathetic secretory nerve) was not affected by either atropine or substance P-antagonist. Continuous chordal stimulation reduced the glandular content of substance P to approximately 50% after 60 min, but similar stimulation of the superior cervical ganglion failed to produce such a reduction. Electron histochemical observation showed that the chordal stimulation caused depletion of substance P from the appropriate nerve fibers within the gland. The reduced secretory capability after continuous stimulation of the chorda at high frequency (20 Hz) was reversed by infusion of a subthreshold dose of exogenous substance P. Histological examination of granular duct cells revealed no degranulation in either chorda-stimulated or substance P-infused rats. The summation of findings suggests that endogenous substance P plays a complementary role in the regulation of parasympathetic nerve-induced fluid secretion in the acinus but is minimally involved in degranulation from granular duct cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0475-2058
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-62
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The role of substance P in parasympathetic nerve-induced secretion in the rat submandibular gland.
pubmed:affiliation
Department of Physiology, Osaka Dental University.
pubmed:publicationType
Journal Article