Linked Life Data

17259086

Source:http://linkedlifedata.com/resource/pubmed/id/17259086

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-1-29
pubmed:abstractText
In normal individuals, the intestine is a site of intense immunological activity due to the continuous stimulation by luminal antigens mostly derived from the normal bacterial flora. This is reflected in the huge amount of IgA produced in the gut and the abundant T cells in the lamina propria and epithelium. It is also becoming clear that products of the normal flora may regulate the cytokine environment within the inductive sites of the mucosal immune responses, such as the Peyer's patches of the small bowel. Thus normal flora could either negatively or positively regulate specific immune responses by dictating the profile of locally released cytokines. For example, it is known that in Crohn's disease the antigens that drive the strongly polarized Th1 tissue-damaging response are derived from the normal bacteria flora. Emerging evidence also indicates that gut microflora can contribute to maintain the mucosal homeostasis by promoting the generation and/or expansion of counter-regulatory mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1878-3562
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S256-60
pubmed:dateRevised
2009-5-20
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Bacteria and mucosal immunity.
pubmed:affiliation
Department of Internal Medicine, Gastroenterology Unit, Tor Vergata University, Rome, Italy. Gi.Monteleone@Med.uniroma2.it
pubmed:publicationType
Journal Article, Review