Linked Life Data

17258941

Source:http://linkedlifedata.com/resource/pubmed/id/17258941

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-4-2
pubmed:abstractText
Scube genes encode a small group of secreted plasma membrane-associated proteins characterised by a N-terminal signal peptide sequence, multiple EGF domains, a N-linked glycosylated spacer region and a C-terminal CUB region. Here we describe expression of the mouse Scube3 gene during early embryonic development. Transcripts were initially localised to neurectoderm of the developing embryo, in the ventral rhombencephalon and caudal neuropore. However, as development progressed, strong expression was detected in ectodermal, endodermal and mesodermal tissues. In particular, the neural tube, branchial arches and fronto-nasal region, the dermomyotome of differentiating somites and the limb buds. Scube3 also demonstrated a highly restricted and specific expression domain in the developing tooth and hair follicle. At later stages, expression was also localised to cartilaginous primordia of the skeleton and regions of intramembranous bone formation in the developing craniofacial region. In addition, Scube3 transcripts were also found in the developing kidney.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1567-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
630-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Expression of the Scube3 epidermal growth factor-related gene during early embryonic development in the mouse.
pubmed:affiliation
Department of Craniofacial Development, Dental Institute, King's College London, Floor 28, Guy's Hospital, London SE1 9RT, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't