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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-2-26
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pubmed:abstractText |
Colon cancers with high-frequency microsatellite instability (MSI-H) develop frameshift mutations in tumor suppressors as part of their pathogenesis. ACVR2 is mutated at its exon 10 polyadenine tract in >80% of MSI-H colon cancers, coinciding with loss of protein. ACVR2 transmits the growth effects of activin via phosphorylation of SMAD proteins to affect gene transcription. The functional effect of activin in colon cancers has not been studied. We developed and characterized a cell model in which we studied how activin signaling affects growth.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ACVR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Activins,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MYC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/activin A,
http://linkedlifedata.com/resource/pubmed/chemical/activin receptor type II-A
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
633-44
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pubmed:dateRevised |
2011-9-22
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pubmed:meshHeading |
pubmed-meshheading:17258738-Active Transport, Cell Nucleus,
pubmed-meshheading:17258738-Activin Receptors, Type I,
pubmed-meshheading:17258738-Activin Receptors, Type II,
pubmed-meshheading:17258738-Activins,
pubmed-meshheading:17258738-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:17258738-Autocrine Communication,
pubmed-meshheading:17258738-Carrier Proteins,
pubmed-meshheading:17258738-Cell Movement,
pubmed-meshheading:17258738-Cell Nucleus,
pubmed-meshheading:17258738-Cell Proliferation,
pubmed-meshheading:17258738-Chromosomes, Human, Pair 2,
pubmed-meshheading:17258738-Colonic Neoplasms,
pubmed-meshheading:17258738-Dose-Response Relationship, Drug,
pubmed-meshheading:17258738-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17258738-HCT116 Cells,
pubmed-meshheading:17258738-Humans,
pubmed-meshheading:17258738-Microsatellite Instability,
pubmed-meshheading:17258738-Mutation,
pubmed-meshheading:17258738-Nuclear Proteins,
pubmed-meshheading:17258738-Phosphorylation,
pubmed-meshheading:17258738-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:17258738-Signal Transduction,
pubmed-meshheading:17258738-Smad2 Protein,
pubmed-meshheading:17258738-Time Factors,
pubmed-meshheading:17258738-Transcriptional Activation,
pubmed-meshheading:17258738-Transfection
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pubmed:year |
2007
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pubmed:articleTitle |
Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin.
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pubmed:affiliation |
Department of Medicine, University of California, San Diego, La Jolla 92093-0063, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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