Linked Life Data

17258692

Source:http://linkedlifedata.com/resource/pubmed/id/17258692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-2-19
pubmed:abstractText
A cerebral growth hormone axis is activated during recovery from brain injury and centrally administered growth hormone can rescue injured neurons. It remains unclear, however, whether this treatment effect occurs directly via neuronal growth hormone receptors. Immunohistochemistry confirmed growth hormone receptor protein on neuronal cell bodies in the rat cortex. Surprisingly, we found that central treatment with bovine growth hormone, which is equipotent to rat growth hormone in the rat periphery, failed to rescue cortical neurons following hypoxic ischemic injury. We further investigated the actions of rat and bovine growth hormone on primary neuron-enriched cultures of fetal rat cortex. In agreement with the in vivo treatment studies, rat but not bovine growth hormone rescued neurons from nutrient deprivation-induced cell death (p<0.05). This neuroprotective effect was inhibited by the selective growth hormone receptor antagonist G120D (p<0.001). Furthermore, rat but not bovine growth hormone had trophic effects on uninjured cultures (p<0.001). Immunocytochemistry showed growth hormone receptor on neurons within the neuron-enriched cultures. We show for the first time that the protective and trophic effects of rat growth hormone are mediated via growth hormone receptors on neurons and that the rodent neuronal growth hormone receptor exhibits unique ligand specificity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
1137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-34
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Distinct neuronal growth hormone receptor ligand specificity in the rat brain.
pubmed:affiliation
The Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't