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rdf:type |
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lifeskim:mentions |
umls-concept:C0003842,
umls-concept:C0030817,
umls-concept:C0205098,
umls-concept:C0205400,
umls-concept:C0205531,
umls-concept:C0226896,
umls-concept:C0442027,
umls-concept:C1135183,
umls-concept:C1521801,
umls-concept:C1527415,
umls-concept:C1717970,
umls-concept:C1999216
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pubmed:issue |
2
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|
pubmed:dateCreated |
2007-1-29
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|
pubmed:abstractText |
In patients who have undergone coronary artery bypass grafting, blood copper levels are elevated for 6 weeks after surgery. Copper is an established risk factor for cardiovascular disease and atherogenesis and promotes oxidative stress, lipid oxidation, cell proliferation, and matrix formation, all components of vein graft disease. This project therefore examined the effect of the copper chelator penicillamine on saphenous vein graft thickening in a pig model.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
494-500
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pubmed:dateRevised |
2007-9-5
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pubmed:meshHeading |
pubmed-meshheading:17258588-Administration, Oral,
pubmed-meshheading:17258588-Anastomosis, Surgical,
pubmed-meshheading:17258588-Animals,
pubmed-meshheading:17258588-Biopsy, Needle,
pubmed-meshheading:17258588-Carotid Artery, Common,
pubmed-meshheading:17258588-Disease Models, Animal,
pubmed-meshheading:17258588-Dose-Response Relationship, Drug,
pubmed-meshheading:17258588-Female,
pubmed-meshheading:17258588-Graft Occlusion, Vascular,
pubmed-meshheading:17258588-Immunohistochemistry,
pubmed-meshheading:17258588-Male,
pubmed-meshheading:17258588-Penicillamine,
pubmed-meshheading:17258588-Photomicrography,
pubmed-meshheading:17258588-Probability,
pubmed-meshheading:17258588-Reference Values,
pubmed-meshheading:17258588-Saphenous Vein,
pubmed-meshheading:17258588-Statistics, Nonparametric,
pubmed-meshheading:17258588-Swine,
pubmed-meshheading:17258588-Tunica Intima
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pubmed:year |
2007
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pubmed:articleTitle |
Orally administered penicillamine is a potent inhibitor of neointimal and medial thickening in porcine saphenous vein-carotid artery interposition grafts.
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pubmed:affiliation |
Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Comparative Study
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