| pubmed-article:17258258 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C1335268 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C0028612 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C1158478 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:17258258 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:17258258 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17258258 | pubmed:dateCreated | 2007-3-5 | lld:pubmed |
| pubmed-article:17258258 | pubmed:abstractText | An integrase dimer can process and integrate a single HIV-1 DNA end in vitro, whereas a tetramer is required to integrate two ends. LEDGF/p75 can potently stimulate integrase activity, but its effects on half- versus full-site integration have not been investigated. Stimulation of half-site but inhibition of full-site integration is revealed here. LEDGF/p75 seems to interfere with integrase oligomerization, but does not inhibit the catalytic activity of pre-assembled complexes. We therefore speculate that LEDGF/p75 function is restricted to a point in the viral lifecycle that occurs after the formation of the preintegration synaptic complex, for example, as a chromatin-associated tethering factor. | lld:pubmed |
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| pubmed-article:17258258 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17258258 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17258258 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17258258 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17258258 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:17258258 | pubmed:author | pubmed-author:EngelmanAlanA | lld:pubmed |
| pubmed-article:17258258 | pubmed:author | pubmed-author:RaghavendraNi... | lld:pubmed |
| pubmed-article:17258258 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17258258 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:17258258 | pubmed:volume | 360 | lld:pubmed |
| pubmed-article:17258258 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17258258 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17258258 | pubmed:pagination | 1-5 | lld:pubmed |
| pubmed-article:17258258 | pubmed:dateRevised | 2011-1-19 | lld:pubmed |
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| pubmed-article:17258258 | pubmed:meshHeading | pubmed-meshheading:17258258... | lld:pubmed |
| pubmed-article:17258258 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17258258 | pubmed:articleTitle | LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration. | lld:pubmed |
| pubmed-article:17258258 | pubmed:affiliation | Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:17258258 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17258258 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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