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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0019704,
umls-concept:C0028612,
umls-concept:C0441712,
umls-concept:C0521026,
umls-concept:C1158478,
umls-concept:C1335268,
umls-concept:C1522492,
umls-concept:C1533691,
umls-concept:C1704241,
umls-concept:C1705422
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pubmed:issue |
1
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pubmed:dateCreated |
2007-3-5
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pubmed:abstractText |
An integrase dimer can process and integrate a single HIV-1 DNA end in vitro, whereas a tetramer is required to integrate two ends. LEDGF/p75 can potently stimulate integrase activity, but its effects on half- versus full-site integration have not been investigated. Stimulation of half-site but inhibition of full-site integration is revealed here. LEDGF/p75 seems to interfere with integrase oligomerization, but does not inhibit the catalytic activity of pre-assembled complexes. We therefore speculate that LEDGF/p75 function is restricted to a point in the viral lifecycle that occurs after the formation of the preintegration synaptic complex, for example, as a chromatin-associated tethering factor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-10219094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-11504911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-11743009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-12407101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-12796494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-15308744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-15718297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-15797927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-15956566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-15958388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-16311605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-16337983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-16439544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-16482214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-16735438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-16774912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-16793062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-16959972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-1847518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-7666512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17258258-8594382
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
360
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-5
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pubmed:dateRevised |
2011-1-19
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pubmed:meshHeading |
pubmed-meshheading:17258258-DNA, Complementary,
pubmed-meshheading:17258258-DNA, Viral,
pubmed-meshheading:17258258-HIV Integrase,
pubmed-meshheading:17258258-HIV-1,
pubmed-meshheading:17258258-Humans,
pubmed-meshheading:17258258-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:17258258-Nucleoproteins,
pubmed-meshheading:17258258-Synaptic Membranes,
pubmed-meshheading:17258258-Viral Proteins,
pubmed-meshheading:17258258-Virus Integration
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pubmed:year |
2007
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pubmed:articleTitle |
LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration.
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pubmed:affiliation |
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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