rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2007-1-29
|
pubmed:abstractText |
Severe myelosuppression is a common side effect of radiotherapy or chemotherapy. Methods have been developed to protect patients by stimulating white blood cell or red blood cell recovery/production using growth factors such as G-CSF or EPO. However, there is no available means to stimulate the full-lineage blood cell recovery from severe myelosuppression. In this study, we used lethally or sublethally irradiated animal models to evaluate the hematopoiesis stimulating effect of IL-12.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0301-472X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
35
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
203-13
|
pubmed:meshHeading |
pubmed-meshheading:17258069-Animals,
pubmed-meshheading:17258069-Blood Cells,
pubmed-meshheading:17258069-Bone Marrow,
pubmed-meshheading:17258069-Dose-Response Relationship, Drug,
pubmed-meshheading:17258069-Dose-Response Relationship, Radiation,
pubmed-meshheading:17258069-Female,
pubmed-meshheading:17258069-Gamma Rays,
pubmed-meshheading:17258069-Gastrointestinal Tract,
pubmed-meshheading:17258069-Graft Survival,
pubmed-meshheading:17258069-Hematopoiesis,
pubmed-meshheading:17258069-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:17258069-Interleukin-12,
pubmed-meshheading:17258069-Mice,
pubmed-meshheading:17258069-Mice, Inbred C57BL,
pubmed-meshheading:17258069-Radiation-Protective Agents,
pubmed-meshheading:17258069-Recovery of Function,
pubmed-meshheading:17258069-Stem Cells,
pubmed-meshheading:17258069-Survival Rate,
pubmed-meshheading:17258069-Time Factors,
pubmed-meshheading:17258069-Whole-Body Irradiation
|
pubmed:year |
2007
|
pubmed:articleTitle |
IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation.
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|