Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-1-29
pubmed:abstractText
Severe myelosuppression is a common side effect of radiotherapy or chemotherapy. Methods have been developed to protect patients by stimulating white blood cell or red blood cell recovery/production using growth factors such as G-CSF or EPO. However, there is no available means to stimulate the full-lineage blood cell recovery from severe myelosuppression. In this study, we used lethally or sublethally irradiated animal models to evaluate the hematopoiesis stimulating effect of IL-12.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-13
pubmed:meshHeading
pubmed-meshheading:17258069-Animals, pubmed-meshheading:17258069-Blood Cells, pubmed-meshheading:17258069-Bone Marrow, pubmed-meshheading:17258069-Dose-Response Relationship, Drug, pubmed-meshheading:17258069-Dose-Response Relationship, Radiation, pubmed-meshheading:17258069-Female, pubmed-meshheading:17258069-Gamma Rays, pubmed-meshheading:17258069-Gastrointestinal Tract, pubmed-meshheading:17258069-Graft Survival, pubmed-meshheading:17258069-Hematopoiesis, pubmed-meshheading:17258069-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:17258069-Interleukin-12, pubmed-meshheading:17258069-Mice, pubmed-meshheading:17258069-Mice, Inbred C57BL, pubmed-meshheading:17258069-Radiation-Protective Agents, pubmed-meshheading:17258069-Recovery of Function, pubmed-meshheading:17258069-Stem Cells, pubmed-meshheading:17258069-Survival Rate, pubmed-meshheading:17258069-Time Factors, pubmed-meshheading:17258069-Whole-Body Irradiation
pubmed:year
2007
pubmed:articleTitle
IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't