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rdf:type |
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lifeskim:mentions |
umls-concept:C0015780,
umls-concept:C0026549,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0036667,
umls-concept:C0080194,
umls-concept:C0234194,
umls-concept:C0312418,
umls-concept:C0392747,
umls-concept:C0442045,
umls-concept:C0555952,
umls-concept:C1280500,
umls-concept:C1637833
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pubmed:issue |
1
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pubmed:dateCreated |
2007-6-4
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pubmed:abstractText |
Colorectal distension of a sufficient intensity evokes several characteristic postural, visceromotor and cardiovascular reflexes in conscious rats that have been extensively utilized for testing putative visceral analgesics. The neural circuitry for these reflexes is encompassed within the spinobulbar region and continues to be robust even after decerebration. Yet, these are not consistently replicated in anesthetized animals, presumably due to medullary depression. In the following studies, we tested the hypothesis that a carefully chosen anesthetic regimen can replicate the pattern of pseudoaffective responses seen in awake animals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1056-8719
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
43-50
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pubmed:meshHeading |
pubmed-meshheading:17257861-Abdominal Muscles,
pubmed-meshheading:17257861-Analgesics, Opioid,
pubmed-meshheading:17257861-Anesthetics,
pubmed-meshheading:17257861-Animals,
pubmed-meshheading:17257861-Autonomic Nervous System,
pubmed-meshheading:17257861-Blood Pressure,
pubmed-meshheading:17257861-Colon,
pubmed-meshheading:17257861-Dilatation, Pathologic,
pubmed-meshheading:17257861-Electromyography,
pubmed-meshheading:17257861-Female,
pubmed-meshheading:17257861-Heart Rate,
pubmed-meshheading:17257861-Morphine,
pubmed-meshheading:17257861-Pain,
pubmed-meshheading:17257861-Pain Threshold,
pubmed-meshheading:17257861-Rats,
pubmed-meshheading:17257861-Rats, Inbred WKY,
pubmed-meshheading:17257861-Rats, Sprague-Dawley,
pubmed-meshheading:17257861-Rats, Wistar,
pubmed-meshheading:17257861-Rectum,
pubmed-meshheading:17257861-Species Specificity,
pubmed-meshheading:17257861-Viscera
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pubmed:articleTitle |
Colorectal distension-induced pseudoaffective changes as indices of nociception in the anesthetized female rat: morphine and strain effects on visceral sensitivity.
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pubmed:affiliation |
Neuroscience Drug Discovery, Pharmaceutical Research Institute, Bristol Myers Squibb Co., Wallingford, CT06492, USA. siva.digavalli@bms.com <siva.digavalli@bms.com>
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pubmed:publicationType |
Journal Article
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