|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2007-2-23
|
|
pubmed:abstractText |
To identify prodrugs of a thiolate histone deacetylase inhibitor NCH-31 that show potent antiproliferative activity and are stable in human plasma, we synthesized several candidate prodrugs of NCH-31. Among these compounds, S-2-methyl-3-phenylpropanoyl compound 2 showed more potent antiproliferative activity and higher stability in human plasma than S-isobutyryl compound NCH-51.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1558-61
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:17257837-Antineoplastic Agents,
pubmed-meshheading:17257837-Blotting, Western,
pubmed-meshheading:17257837-Cell Line, Tumor,
pubmed-meshheading:17257837-Chromatography, High Pressure Liquid,
pubmed-meshheading:17257837-Drug Screening Assays, Antitumor,
pubmed-meshheading:17257837-Enzyme Inhibitors,
pubmed-meshheading:17257837-Histone Deacetylase Inhibitors,
pubmed-meshheading:17257837-Humans,
pubmed-meshheading:17257837-Prodrugs,
pubmed-meshheading:17257837-Thiazoles
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.
|
|
pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. suzuki@phar.nagoya-cu.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
