Source:http://linkedlifedata.com/resource/pubmed/id/17257673
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-6-8
|
| pubmed:abstractText |
The classification, scoring systems, and response criteria for myelodysplastic syndromes (MDS) have recently been updated and have become widely accepted. In addition, several new effective targeted drugs for patients with MDS have been developed. The current article provides a summary of updated and newly proposed markers, criteria, and standards in MDS, with special reference to the diagnostic interface and refinements in evaluations and scoring. Concerning the diagnostic interface, minimal diagnostic criteria for MDS are proposed, and for patients with unexplained cytopenia who do not fulfill these criteria, the term 'idiopathic cytopenia of uncertain significance' (ICUS) is suggested. In addition, new diagnostic and prognostic parameters, histopathologic and immunologic determinants, proposed refinements in scoring systems, and new therapeutic approaches are discussed. Respective algorithms and recommendations should facilitate diagnostic and prognostic evaluations in MDS, selection of patients for therapies, and the conduct of clinical trials.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0145-2126
|
| pubmed:author |
pubmed-author:BennettJohn MJM,
pubmed-author:FonatschChristaC,
pubmed-author:GermingUlrichU,
pubmed-author:GreenbergPeterP,
pubmed-author:HaaseDetlefD,
pubmed-author:HaferlachTorstenT,
pubmed-author:HornyHans-PeterHP,
pubmed-author:KolbHans-JochenHJ,
pubmed-author:KriegerOttoO,
pubmed-author:LokenMichaelM,
pubmed-author:OgataKiyoyukiK,
pubmed-author:OrfaoAlbertoA,
pubmed-author:PfeilstöckerMichaelM,
pubmed-author:RüterBjörnB,
pubmed-author:SperrWolfgang RWR,
pubmed-author:StauderReinhardR,
pubmed-author:ValentPeterP,
pubmed-author:WellsDenise ADA,
pubmed-author:van de LoosdrechtArjanA
|
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
727-36
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:17257673-Algorithms,
pubmed-meshheading:17257673-Clinical Trials as Topic,
pubmed-meshheading:17257673-Diagnosis, Differential,
pubmed-meshheading:17257673-Guidelines as Topic,
pubmed-meshheading:17257673-Humans,
pubmed-meshheading:17257673-Myelodysplastic Syndromes,
pubmed-meshheading:17257673-Prognosis
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference.
|
| pubmed:affiliation |
Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. peter.valent@meduniwien.ac.at
|
| pubmed:publicationType |
Journal Article,
Review,
Consensus Development Conference
|