Linked Life Data

1725728

Source:http://linkedlifedata.com/resource/pubmed/id/1725728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1992-6-3
pubmed:abstractText
The effect of the general anaesthetic, benzyl alcohol, on the nicotinic cholinergic receptor (AChR) was evaluated at the single channel level using the patch-clamp technique. Benzyl alcohol decreases both the conductance (about 2-fold with 40 mM benzyl alcohol) and the mean open time (about 2.5-fold) of the AChR channels. When modified channels are activated by high ACh concentrations, groups of brief channel openings are observed. Each group is in turn composed of a higher number of openings than in non-treated receptors. Similar modifications are observed when benzyl alcohol is applied from the cytoplasmic side of the membrane, suggesting that the general anaesthetic interacts with a nonspecific site, possibly the lipid-protein interface.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
681-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Acetylcholine receptor channel properties are modified by benzyl alcohol.
pubmed:affiliation
Instituto de Investigaciones Bioquimicas, CONICET, Bahia Blanca, Argentina.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't