Linked Life Data

17254505

Source:http://linkedlifedata.com/resource/pubmed/id/17254505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-1-26
pubmed:abstractText
Lymphatic filariasis and onchocerciasis are debilitating diseases caused by parasitic filarial nematodes. These nematodes have evolved a mutualistic symbiosis with intracellular bacteria of the genus Wolbachia, which are required for nematode embryogenesis and survival. The essential role of these bacteria in the biology of the nematode and their demonstrated involvement in the pathogenesis of filariasis make Wolbachia a promising novel chemotherapeutic target for the control of filarial infection and disease. This article reviews the recent findings, which highlight potential processes that form the basis of the symbiosis, the role of Wolbachia in filarial pathogenesis, and the efficacy of Wolbachia-targeted antibiotic chemotherapy in human trials. Future prospects for the development of an anti-Wolbachia treatment regimen suitable for integration into mass drug administration programs are also discussed.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Jan
pubmed:issn
1523-3847
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-9
pubmed:year
2007
pubmed:articleTitle
Wolbachia in filarial parasites: targets for filarial infection and disease control.
pubmed:affiliation
Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, UK.
pubmed:publicationType
Journal Article