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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1992-5-12
|
| pubmed:abstractText |
The effects of NG-nitro-L-arginine (L-NNA), a nitric oxide (NO) synthase inhibitor, on renal vascular response to endothelin-3 (ET-3) were studied in anesthetized dogs. Intrarenal arterial (i.r.a.) infusion of ET-3 (5 and 25 ng/kg/min for 2 min) elicited a dose-dependent increase in renal blood flow (RBF) with no change in the systemic blood pressure (BP). Marked attenuation of the renal vasodilatory response to ET-3 was observed following the administration of L-NNA (75 micrograms/kg/min i.r.a. for 20 min), and there was a partial reversion when L-arginine (100 mg/kg i.v.) was given. Continuous administration of ET-3 at a rate of 5 ng/kg/min i.r.a. for 25 min increased RBF with no change in BP and heart rate (HR). The glomerular filtration rate (GFR) remained unchanged throughout the experiment, the result being a significant decrease in the filtration fraction (FF). The significant increase in urine flow rate (UF) was associated with a marked reduction in urine osmolarity (Uosm) during ET-3 infusion, but urinary excretion of sodium (UNaV) remained unchanged. Pretreatment with L-NNA abolished the ET-3-induced renal vasodilation. RBF decreased immediately after the start of ET-3 infusion into animals treated with L-NNA. Thus, ET-3 is a diuretic and renal vasodilatory peptide, the vascular effects of which may be mediated by production of endothelial NO in the kidney.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0160-2446
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17 Suppl 7
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S332-4
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:1725372-Anesthesia,
pubmed-meshheading:1725372-Animals,
pubmed-meshheading:1725372-Arginine,
pubmed-meshheading:1725372-Dogs,
pubmed-meshheading:1725372-Endothelins,
pubmed-meshheading:1725372-Female,
pubmed-meshheading:1725372-Hemodynamics,
pubmed-meshheading:1725372-Kidney,
pubmed-meshheading:1725372-Kidney Function Tests,
pubmed-meshheading:1725372-Male,
pubmed-meshheading:1725372-Nitroarginine,
pubmed-meshheading:1725372-Renal Circulation,
pubmed-meshheading:1725372-Urodynamics,
pubmed-meshheading:1725372-Vasodilation
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Effects of NG-nitro-L-arginine on renal hemodynamic responses to endothelin-3 in anesthetized dogs.
|
| pubmed:affiliation |
Department of Pharmacology, Osaka City University Medical School, Japan.
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| pubmed:publicationType |
Journal Article
|