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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-2-15
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pubmed:abstractText |
A series of 2-thiazolylhydrazone derivatives have been investigated for the ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO) selectively. All of the compounds showed high activity against both the MAO-A and the MAO-B isoforms with pKi values ranging between 5.92 and 8.14 for the MAO-A and between 4.69 and 9.09 for the MAO-B isoforms. Both the MAO-A and the MAO-B isoforms, deposited in the Protein Data Bank as model 2BXR and 1GOS, respectively, were considered in a computational study performed with docking techniques on the most active and MAO-B-selective inhibitor, 18.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:AlcaroStefanoS,
pubmed-author:BefaniOliviaO,
pubmed-author:BolascoAdrianaA,
pubmed-author:CardiaMaria CMC,
pubmed-author:ChimentiFrancoF,
pubmed-author:ChimentiPaolaP,
pubmed-author:DistintoSimonaS,
pubmed-author:GraneseAriannaA,
pubmed-author:MaccioniEliasE,
pubmed-author:OrtusoFrancescoF,
pubmed-author:SecciDanielaD,
pubmed-author:TuriniPaolaP
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pubmed:issnType |
Print
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|
pubmed:day |
22
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|
pubmed:volume |
50
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
707-12
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pubmed:meshHeading |
|
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pubmed:year |
2007
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pubmed:articleTitle |
Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives.
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pubmed:affiliation |
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" and Centro di Biologia Molecolare del CNR, Università degli Studi di Roma "La Sapienza", Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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