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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1976-3-1
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pubmed:abstractText |
The interrelationship between apolipoprotein B in very low density lipoprotein (VLDL-B) and in low density lipoprotein (LDL-B) was studied in seven normal and hyperlipidemic men and women, with purified radioiodinated VLDL. The time-course of the appearance of radioactivity in LDL was followed. As the specific activity curves intersected at the masimal height of the LDL-B curve, it was inferred that all or most LDL-B peptide is derived from VLDL-B peptide. This transfer was further quantitated in seven normotriglyceridemic subjects by simultaneous i.v. injection of purified 131I-VLDL and 125I-LDL. By a deconvolution method, a quantitative description of the rate of entry of 131Ivldl-b into 131I-LDL-B was derived by analysis of 131I-LDL-B and 125I-ldl-b radioactivity in plasma. The results indicate that approximately 90% of VLDL-B mass is converted into LDL-B in subjects with normal serum triglyceride concentrations. The synthetic rates of VLDL-B and LDL-B peptide were simultaneously measured in six normal subjects, and two patients with heterozygous familial hypercholesterolemia (type IIa). The turnover rates for VLDL-B and LDL-B peptide were similar in these subjects. The findings in the three parts of this study were consistent with the view that most if not all VLDL-B is converted into LDL-B peptide, and most if not all LDL-B is derived from VLDL-B peptide in normotriglyceridemic subjects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-13252080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-13484460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-13513748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-13645237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-13788500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-14311634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-14870278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4128882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4129717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4335139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4336943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4349053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4351944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4359865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4359866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4364079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4370423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4930042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-4981584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-5130947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-5480854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-5704745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-5822579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-5903741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-6049671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/172533-6079904
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1481-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:172533-Adult,
pubmed-meshheading:172533-Apoproteins,
pubmed-meshheading:172533-Cholesterol,
pubmed-meshheading:172533-Chylomicrons,
pubmed-meshheading:172533-Female,
pubmed-meshheading:172533-Heterozygote,
pubmed-meshheading:172533-Humans,
pubmed-meshheading:172533-Hypercholesterolemia,
pubmed-meshheading:172533-Hyperlipidemias,
pubmed-meshheading:172533-Lipoproteins, LDL,
pubmed-meshheading:172533-Lipoproteins, VLDL,
pubmed-meshheading:172533-Male,
pubmed-meshheading:172533-Middle Aged,
pubmed-meshheading:172533-Triglycerides
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pubmed:year |
1975
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pubmed:articleTitle |
Conversion of very low density lipoprotein to low density lipoprotein. A metabolic study of apolipoprotein B kinetics in human subjects.
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pubmed:publicationType |
Journal Article
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