|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003483,
umls-concept:C0010453,
umls-concept:C0030685,
umls-concept:C0039005,
umls-concept:C0391871,
umls-concept:C0521116,
umls-concept:C0596019,
umls-concept:C0596235,
umls-concept:C0680255,
umls-concept:C1135918,
umls-concept:C1283071,
umls-concept:C1963578
|
|
pubmed:dateCreated |
1992-5-7
|
|
pubmed:abstractText |
1. The effect of exogenous ATP on transmembrane currents and on the cytoplasmic Ca2+ has been investigated in single cultured smooth muscle cells of pig aorta. 2. ATP applied to cells held at a potential of -50 mV evoked a transient inward current and a transient rise in [Ca2+]i. At a potential of +20 mV the ATP-induced increase in [Ca2+]i was accompanied by an outward current. 3. At a potential of -50 mV, ATP evoked in Ca(2+)-free solution an inward current which was similar to that in the presence of external Ca2+. A second application of ATP in Ca(2+)-free solution induced a much smaller current. 4. ATP induced in Ca(2+)-free solution a pronounced transient stimulation of the 45Ca2+ efflux from confluent smooth muscle monolayers. 5. The I-V curve of the ATP-activated current has a reversal potential close to 0 mV. A reduction of external Cl- shifts this reversal potential in accordance with the change of the Cl- equilibrium potential. 6. It is concluded that ATP causes a release of calcium from intracellular stores. The ensuing increase of [Ca2+]i activates a Cl- current, which can depolarize the cell membrane and thereby promote a voltage-gated Ca2+ entry.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-1696988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2439921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2442722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2445404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2445970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2445979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2459375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2473199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2517986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2559977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2597109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2764093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2783453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-2918318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-3032169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-3116214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-3426590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-3502344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-3533627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-3838314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-4327464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1725183-6270629
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0022-3751
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
440
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
623-34
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1725183-Adenosine Triphosphate,
pubmed-meshheading:1725183-Animals,
pubmed-meshheading:1725183-Aorta, Thoracic,
pubmed-meshheading:1725183-Calcium,
pubmed-meshheading:1725183-Cells, Cultured,
pubmed-meshheading:1725183-Chlorides,
pubmed-meshheading:1725183-Electrophysiology,
pubmed-meshheading:1725183-Ion Channels,
pubmed-meshheading:1725183-Muscle, Smooth,
pubmed-meshheading:1725183-Swine
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
ATP-induced Ca2+ release and Cl- current in cultured smooth muscle cells from pig aorta.
|
|
pubmed:affiliation |
Laboratorium voor Fysiologie, KU Leuven, Belgium.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
