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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-1-25
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pubmed:abstractText |
Axonal loss is thought to contribute to the persistence of visual loss in optic neuritis and multiple sclerosis (MS). The mechanisms of injury are poorly understood. The authors investigated the contribution of mitochondrial oxidative stress and the effects of modulating mitochondrial antioxidant gene expression in the optic nerves of mice induced with experimental allergic encephalomyelitis (EAE), with a focus on long-term neuroprotection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
681-91
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17251466-Animals,
pubmed-meshheading:17251466-Cell Culture Techniques,
pubmed-meshheading:17251466-Dependovirus,
pubmed-meshheading:17251466-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:17251466-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:17251466-Fluorescent Dyes,
pubmed-meshheading:17251466-Gene Therapy,
pubmed-meshheading:17251466-Magnetic Resonance Imaging,
pubmed-meshheading:17251466-Mice,
pubmed-meshheading:17251466-Mice, Inbred DBA,
pubmed-meshheading:17251466-Mitochondria,
pubmed-meshheading:17251466-Myelin Sheath,
pubmed-meshheading:17251466-Optic Nerve,
pubmed-meshheading:17251466-Optic Neuritis,
pubmed-meshheading:17251466-Oxidative Stress,
pubmed-meshheading:17251466-RNA, Catalytic,
pubmed-meshheading:17251466-Reactive Oxygen Species,
pubmed-meshheading:17251466-Retinal Ganglion Cells,
pubmed-meshheading:17251466-Superoxide Dismutase,
pubmed-meshheading:17251466-Transfection
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pubmed:year |
2007
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pubmed:articleTitle |
Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis.
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pubmed:affiliation |
Department of Ophthalmology, University of Florida, College of Medicine, Gainesville, FL 32610-0284, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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