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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-2-23
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pubmed:abstractText |
Melanin concentrating hormone (MCH) plays an important role in the regulation of food intake and energy balance in mammals. MCH-1 receptor (MCH1R) deficient mice are lean and resistant to diet-induced obesity. As such, MCH1R antagonists are believed to have potential as possible treatments for obesity. The discovery of a novel class of tetralin ureas as potent MCH1R antagonists is described herein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1718-21
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pubmed:meshHeading |
pubmed-meshheading:17251014-Animals,
pubmed-meshheading:17251014-Binding, Competitive,
pubmed-meshheading:17251014-CHO Cells,
pubmed-meshheading:17251014-Cricetinae,
pubmed-meshheading:17251014-Cricetulus,
pubmed-meshheading:17251014-Drug Design,
pubmed-meshheading:17251014-Humans,
pubmed-meshheading:17251014-Mice,
pubmed-meshheading:17251014-Mice, Knockout,
pubmed-meshheading:17251014-Rats,
pubmed-meshheading:17251014-Receptors, Somatostatin,
pubmed-meshheading:17251014-Structure-Activity Relationship,
pubmed-meshheading:17251014-Tetrahydronaphthalenes,
pubmed-meshheading:17251014-Tissue Distribution,
pubmed-meshheading:17251014-Urea
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pubmed:year |
2007
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pubmed:articleTitle |
Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists.
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pubmed:affiliation |
Pharmacopeia Drug Discovery Inc., PO Box 5350, Princeton, NJ 08543-5350, USA. tguo@pcop.com
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pubmed:publicationType |
Journal Article
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