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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-2-23
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pubmed:abstractText |
A new efficient and flexible synthesis of fluorescently labeled sphingosine derivatives from commercially available Garner aldehyde (8) is described. For this, appropriate alkenylated borondipyrromethene (BODIPY) dyes were synthesized and used for the first time in a cross-metathesis reaction, the key step of the approach. The labeled sphingosines with appropriate chain length were accepted as substrates by sphingosine kinases (SPHKs), yielding the corresponding phosphorylated products. One of these derivatives (11d) was identified as the first reported selective substrate for SPHK-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-3263
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1842-5
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pubmed:meshHeading |
pubmed-meshheading:17249735-Aldehydes,
pubmed-meshheading:17249735-Boron Compounds,
pubmed-meshheading:17249735-Chromatography, High Pressure Liquid,
pubmed-meshheading:17249735-Fluorescent Dyes,
pubmed-meshheading:17249735-Indicators and Reagents,
pubmed-meshheading:17249735-Kinetics,
pubmed-meshheading:17249735-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17249735-Phosphorylation,
pubmed-meshheading:17249735-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:17249735-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:17249735-Sphingosine
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis of borondipyrromethene (BODIPY)-labeled sphingosine derivatives by cross-metathesis reaction.
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pubmed:affiliation |
Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.
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pubmed:publicationType |
Journal Article
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