Linked Life Data

17245091

Source:http://linkedlifedata.com/resource/pubmed/id/17245091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-1-24
pubmed:abstractText
The conventional wisdom is that early exposure to allergenic food proteins during pregnancy, lactation, or infancy leads to food allergies, and that prevention strategies should therefore aim to eliminate allergenic food proteins during pregnancy, breastfeeding, and early childhood. Prolonged exclusive breastfeeding and delayed weaning onto solid foods is therefore seen as an effective public health policy to prevent allergies. However, there is little epidemiological data to support this belief. Interventional studies on dietary elimination have failed to reduce IgE-mediated food allergies. Conversely, there is preclinical data and some clinical data to suggest that early cutaneous exposure to food protein through inflamed skin leads to allergic sensitization and that early oral exposure results in the induction of tolerance. New strategies to prevent food allergy in infants need to be put to test in randomized controlled interventional studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1661-6677
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-8; discussion 68-72
pubmed:dateRevised
2007-9-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The concept of oral tolerance induction to foods.
pubmed:affiliation
Paediatric Unit, Department of Medicine, King's College London, Guys and St. Thomas' NHS Foundation Trust, St. Thomas' Hospital, Lambeth Palace Road, London, UK. gideon.lack@kcl.ac.uk
pubmed:publicationType
Journal Article, Review