Linked Life Data

17243174

Source:http://linkedlifedata.com/resource/pubmed/id/17243174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2007-10-31
pubmed:abstractText
The cytoplasmic hybrid (cybrid) technique allows investigators to express selected mitochondrial DNA (mtDNA) sequences against fixed nuclear DNA (nDNA) backgrounds. Cybrids have been used to study the effects of known mtDNA mutations on mitochondrial biochemistry, mtDNA-nDNA inter-species compatibility, and mtDNA integrity in persons without mtDNA mutations defined previously. This review discusses events leading up to creation of the cybrid technique, as well as data obtained via application of the cybrid strategies listed above. Although interpreting cybrid data requires awareness of technique limitations, valuable insights into mtDNA genotype-functional phenotype relationships are suggested.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0360-4012
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3416-28
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies.
pubmed:affiliation
Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. rhs7e@virginia.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural