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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-23
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pubmed:abstractText |
Gastroesophageal reflux disease is a condition frequently associated with esophagitis and motor abnormalities. Recent evidence suggests that proinflammatory cytokines, such as interleukin (IL)-1beta and IL-6, may be implicated because they reduce esophageal muscle contractility, but these results derive from in vitro or animal models of esophagitis. This study used human esophageal cells and tissues to identify the cellular source of cytokines in human esophagitis investigate whether cytokines can be induced by gastric refluxate, and examine whether esophageal tissue- or cell-derived mediators affect muscle contractility.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:BiancaniPieroP,
pubmed-author:CatanzaroAndrewA,
pubmed-author:ChakAmitabhA,
pubmed-author:ChengLingL,
pubmed-author:CooperGregory SGS,
pubmed-author:FiocchiClaudioC,
pubmed-author:HarnettKaren MKM,
pubmed-author:IsenbergGerardG,
pubmed-author:KatzJeffry AJA,
pubmed-author:McCormickThomasT,
pubmed-author:O'SheaRobertR,
pubmed-author:PhillipsManijehM,
pubmed-author:PostAnthony BAB,
pubmed-author:RayMonicaM,
pubmed-author:RiederFlorianF,
pubmed-author:SivakMichael VMV,
pubmed-author:WestGail AGA,
pubmed-author:WillisJoseph EJE,
pubmed-author:WongRichardR
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
154-65
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17241868-Animals,
pubmed-meshheading:17241868-Biopsy,
pubmed-meshheading:17241868-Cats,
pubmed-meshheading:17241868-Cell Line,
pubmed-meshheading:17241868-Esophageal Motility Disorders,
pubmed-meshheading:17241868-Esophagitis,
pubmed-meshheading:17241868-Esophagus,
pubmed-meshheading:17241868-Gastric Juice,
pubmed-meshheading:17241868-Gastroesophageal Reflux,
pubmed-meshheading:17241868-Humans,
pubmed-meshheading:17241868-Interleukin-1beta,
pubmed-meshheading:17241868-Interleukin-6,
pubmed-meshheading:17241868-Keratinocytes,
pubmed-meshheading:17241868-Mucous Membrane,
pubmed-meshheading:17241868-Muscle, Smooth,
pubmed-meshheading:17241868-Muscle Contraction,
pubmed-meshheading:17241868-Organ Culture Techniques,
pubmed-meshheading:17241868-Polymerase Chain Reaction,
pubmed-meshheading:17241868-RNA, Messenger
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pubmed:year |
2007
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pubmed:articleTitle |
Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities.
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pubmed:affiliation |
Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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