| pubmed-article:17241708 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17241708 | lifeskim:mentions | umls-concept:C0024530 | lld:lifeskim |
| pubmed-article:17241708 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:17241708 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:17241708 | lifeskim:mentions | umls-concept:C1527177 | lld:lifeskim |
| pubmed-article:17241708 | lifeskim:mentions | umls-concept:C0441513 | lld:lifeskim |
| pubmed-article:17241708 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:17241708 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17241708 | pubmed:dateCreated | 2007-2-16 | lld:pubmed |
| pubmed-article:17241708 | pubmed:abstractText | Due to the complex life cycle and high antigenic diversity of the malaria parasite, a multistage vaccine may be necessary for optimal protection against the disease. Our previous studies demonstrated that a blood-stage recombinant protein PfCP-2.9 has significant potential for vaccine development and is currently in human clinical trials. This study constructed two recombinant antigens derived from the Plasmodium falciparum CSP, designated PfCSP-C and PfCSP-RC. They were expressed as secreted proteins at high yield (1-3 g/l) in Pichia pastoris and purified by a two-step purification procedure. There was no evidence of antigen competition in mice and rabbits co-immunized with the pre-erythrocytic antigens and PfCP-2.9. Moreover, the immune sera recognized both the blood-stage parasite and sporozoite, and interacted with the NANP repeats of PfCSP. Rabbits antisera to combination antigens strongly inhibited blood-stage parasite growth in vitro. These results suggest that the recombinant antigens are potential candidates for multistage combination vaccines against malarial parasite. | lld:pubmed |
| pubmed-article:17241708 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17241708 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17241708 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17241708 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17241708 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17241708 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17241708 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:17241708 | pubmed:author | pubmed-author:LocN KNK | lld:pubmed |
| pubmed-article:17241708 | pubmed:author | pubmed-author:PanWeiqingW | lld:pubmed |
| pubmed-article:17241708 | pubmed:author | pubmed-author:ZhangQingfeng... | lld:pubmed |
| pubmed-article:17241708 | pubmed:author | pubmed-author:XueXiangyangX | lld:pubmed |
| pubmed-article:17241708 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17241708 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17241708 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:17241708 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17241708 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17241708 | pubmed:pagination | 2112-9 | lld:pubmed |
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| pubmed-article:17241708 | pubmed:meshHeading | pubmed-meshheading:17241708... | lld:pubmed |
| pubmed-article:17241708 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17241708 | pubmed:articleTitle | Construction and evaluation of a multistage combination vaccine against malaria. | lld:pubmed |
| pubmed-article:17241708 | pubmed:affiliation | Department of Etiologic Biology and State Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China. | lld:pubmed |
| pubmed-article:17241708 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17241708 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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