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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-2-16
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pubmed:abstractText |
The safety of a propagation-defective Venezuelan equine encephalitis virus (VEEV) replicon particle vaccine was examined in mice. After intracranial inoculation we observed approximately 5% body weight loss, modest inflammatory changes in the brain, genome replication, and foreign gene expression. These changes were transient and significantly less severe than those caused by TC-83, a live-attenuated vaccinal strain of VEEV that has been safely used to immunize military personnel and laboratory workers. Replicon particles injected intramuscularly or intravenously were detected at limited sites 3 days post-administration, and were undetectable by day 22. There was no evidence of dissemination to spinal cord or brain after systemic administration. These results demonstrate that propagation-defective VEEV replicon particles are minimally neurovirulent and lack neuroinvasive potential.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:AdkinsKarissaK,
pubmed-author:ArendtHeatherH,
pubmed-author:BrownTom PTP,
pubmed-author:DeStefanoJoanneJ,
pubmed-author:GangolliSeemaS,
pubmed-author:KowalskiJacekJ,
pubmed-author:LongDeborahD,
pubmed-author:NatukRobert JRJ,
pubmed-author:ObregonJenniferJ,
pubmed-author:ParksChristopher LCL,
pubmed-author:RenJianJ,
pubmed-author:TummoloDonnaD,
pubmed-author:UdemStephen ASA
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2296-305
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pubmed:meshHeading |
pubmed-meshheading:17239997-Animals,
pubmed-meshheading:17239997-Body Weight,
pubmed-meshheading:17239997-Brain,
pubmed-meshheading:17239997-Encephalitis Virus, Venezuelan Equine,
pubmed-meshheading:17239997-Encephalomyelitis, Venezuelan Equine,
pubmed-meshheading:17239997-Injections, Intramuscular,
pubmed-meshheading:17239997-Injections, Intravenous,
pubmed-meshheading:17239997-Mice,
pubmed-meshheading:17239997-RNA, Viral,
pubmed-meshheading:17239997-Replicon,
pubmed-meshheading:17239997-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17239997-Spinal Cord,
pubmed-meshheading:17239997-Vaccines, Attenuated,
pubmed-meshheading:17239997-Viral Envelope Proteins,
pubmed-meshheading:17239997-Virus Replication
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pubmed:year |
2007
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pubmed:articleTitle |
Evaluation of neurovirulence and biodistribution of Venezuelan equine encephalitis replicon particles expressing herpes simplex virus type 2 glycoprotein D.
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pubmed:affiliation |
Vaccine Discovery Department, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA. kowalsj@wyeth.com
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pubmed:publicationType |
Journal Article
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