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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-2-23
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pubmed:abstractText |
Novel analogues of the V-ATPase inhibitors archazolid A and B with modifications of the free hydroxyl groups and the side chain were designed by molecular modeling, synthesized by derivatization of the parent natural product and evaluated for V-ATPase inhibition and growth inhibition of murine connective tissue cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1732-5
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pubmed:dateRevised |
2008-1-16
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pubmed:meshHeading |
pubmed-meshheading:17239591-Animals,
pubmed-meshheading:17239591-Antimitotic Agents,
pubmed-meshheading:17239591-Cell Line,
pubmed-meshheading:17239591-Drug Design,
pubmed-meshheading:17239591-Enzyme Inhibitors,
pubmed-meshheading:17239591-Indicators and Reagents,
pubmed-meshheading:17239591-Macrolides,
pubmed-meshheading:17239591-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17239591-Mice,
pubmed-meshheading:17239591-Models, Molecular,
pubmed-meshheading:17239591-Molecular Conformation,
pubmed-meshheading:17239591-Myxococcales,
pubmed-meshheading:17239591-Structure-Activity Relationship,
pubmed-meshheading:17239591-Thiazoles,
pubmed-meshheading:17239591-Vacuolar Proton-Translocating ATPases
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pubmed:year |
2007
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pubmed:articleTitle |
Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor.
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pubmed:affiliation |
Helmholtz-Zentrum für Infektionsforschung GmbH, Medizinische Chemie, Inhoffenstrasse 7, 38124 Braunschweig, Germany. dirk.menche@heimholtz-hzi.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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