Linked Life Data

17239291

Source:http://linkedlifedata.com/resource/pubmed/id/17239291

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-1-22
pubmed:abstractText
Rash and other cutaneous adverse events are class-effect toxicities seen with therapeutic agents such as the small-molecule tyrosine kinase inhibitors erlotinib and gefitinib and monoclonal antibodies cetuximab and panitumumab, targeting the epidermal growth factor receptor (EGFR) in the treatment of cancer. Rash has been reported in approximately two thirds of patients treated with these agents in phase II/III clinical trials in different tumor types. The rash that occurs with EGFR-targeted agents is generally mild to moderate; severe (grade 3/4) rash is rare (< 15% in non-small-cell lung carcinoma trials). In a number of clinical trials, the association of the incidence and severity of rash with response and survival after treatment with erlotinib or gefitinib has been analyzed. Although the significance of the association is yet to be determined, in most studies, a positive correlation between rash and clinical outcomes with EGFR-targeted therapy has been demonstrated. Therefore, the potential of using rash as a surrogate marker for efficacy of EGFR inhibitors in lung cancer therapy exists and needs to be further explored. This article provides a review of the data evaluating the association between rash and treatment outcomes and summarizes the current knowledge regarding the significance of this association. Understanding the biology/etiology of the rash resulting from EGFR inhibitors and assessing its correlation with treatment outcomes in large, prospective trials will help define the role of rash as a surrogate marker for efficacy of EGFR-targeted therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1525-7304
pubmed:author
pubmed:issnType
Print
pubmed:volume
8 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S7-14
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer.
pubmed:affiliation
Albert Einstein College of Medicine, Bronx, NY 10467, USA. rperezso@montefiore.org
pubmed:publicationType
Journal Article, Review