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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-22
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pubmed:abstractText |
Nogo constitutes a family of neurite outgrowth inhibitors contributing to a failure of axonal regeneration in the adult central nervous system (CNS). Nogo-A is expressed exclusively on oligodendrocytes where Nogo-66 segment binds to Nogo receptor (NgR) expressed on neuronal axons. NgR signalling requires a coreceptor p75(NTR) or TROY in combination with an adaptor LINGO-1. To characterize the cell types expressing the NgR complex in the human CNS, we studied demyelinating lesions of multiple sclerosis (MS) brains by immunohistochemistry. TROY and LINGO-1 were identified in subpopulations of reactive astrocytes, macrophages/microglia and neurones but not in oligodendrocytes. TROY was up-regulated, whereas LINGO-1 was reduced in MS brains by Western blot. These results suggest that the ternary complex of NgR/TROY/LINGO-1 expressed on astrocytes, macrophages/microglia and neurones, by interacting with Nogo-A on oligodendrocytes, might modulate glial-neuronal interactions in demyelinating lesions of MS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0305-1846
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
99-107
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pubmed:dateRevised |
2007-7-25
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pubmed:meshHeading |
pubmed-meshheading:17239012-Adult,
pubmed-meshheading:17239012-Aged,
pubmed-meshheading:17239012-Astrocytes,
pubmed-meshheading:17239012-Blotting, Western,
pubmed-meshheading:17239012-Cell Line,
pubmed-meshheading:17239012-Cells, Cultured,
pubmed-meshheading:17239012-Demyelinating Diseases,
pubmed-meshheading:17239012-Female,
pubmed-meshheading:17239012-Humans,
pubmed-meshheading:17239012-Immunohistochemistry,
pubmed-meshheading:17239012-Macrophages,
pubmed-meshheading:17239012-Male,
pubmed-meshheading:17239012-Membrane Proteins,
pubmed-meshheading:17239012-Microglia,
pubmed-meshheading:17239012-Middle Aged,
pubmed-meshheading:17239012-Multiple Sclerosis,
pubmed-meshheading:17239012-Nerve Tissue Proteins,
pubmed-meshheading:17239012-Neurons,
pubmed-meshheading:17239012-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:17239012-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17239012-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.
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pubmed:affiliation |
Department of Bioinformatics, Meiji Pharmaceutical University, Tokyo, Japan. satoj@my-pharm.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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