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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1992-3-18
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pubmed:abstractText |
Estrogen affects gonadotrophin levels and sex behavior in monkeys. This action could be via inhibitory GABA-ergic neurons in the hypothalamus. We tested for direct estrogen actions on such neurons. Seven days after ovariectomy (OVX) or OVX + estrogen treatment (10 mg estradiol valerate in 1 ml sesame oil s.c. on the day of OVX), light- and electron-microscopic double immunostaining procedures were used for simultaneous visualization of immunoreactivity for progesterone receptors (PR) and glutamic acid decarboxylase (GAD), and to detect ultrastructural changes in PR-containing neurons in the arcuate and ventromedial hypothalamic nuclei of colchicine- and noncolchicine-treated African green monkeys (Cercopithecus aethiops). Immunoreactivity for PR was found only in cell nuclei, and estrogen treatment enhanced the intensity of the immunostaining: in estrogen-treated monkeys in the arcuate nucleus 62%, while in the ventromedial nucleus 42% of the neurons contained PR-immunoreactive nuclei. All of the PR-containing neurons were immunopositive for GAD in colchicine-pretreated monkeys. OVX induced whorl body formation, while estrogen treatment of OVX animals resulted in a large number of nematosomes. While all of the whorl bodies and the majority of nematosomes were observed in PR-immunopositive GAD neurons, nematosomes were also found in non-PR-containing GAD-immunoreactive cells.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/estradiol valerate,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0028-3835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
571-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1723787-Animals,
pubmed-meshheading:1723787-Cercopithecus aethiops,
pubmed-meshheading:1723787-Estradiol,
pubmed-meshheading:1723787-Estrogens,
pubmed-meshheading:1723787-Female,
pubmed-meshheading:1723787-Hypothalamus,
pubmed-meshheading:1723787-Immunologic Techniques,
pubmed-meshheading:1723787-Microscopy, Electron,
pubmed-meshheading:1723787-Neurons,
pubmed-meshheading:1723787-Ovariectomy,
pubmed-meshheading:1723787-Receptors, Progesterone,
pubmed-meshheading:1723787-Staining and Labeling,
pubmed-meshheading:1723787-gamma-Aminobutyric Acid
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pubmed:year |
1991
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pubmed:articleTitle |
Estrogen induces ultrastructural changes in progesterone receptor-containing GABA neurons of the primate hypothalamus.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Conn.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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