| pubmed-article:17237785 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17237785 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:17237785 | lifeskim:mentions | umls-concept:C0010837 | lld:lifeskim |
| pubmed-article:17237785 | lifeskim:mentions | umls-concept:C0015283 | lld:lifeskim |
| pubmed-article:17237785 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:17237785 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:17237785 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:17237785 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:17237785 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17237785 | pubmed:dateCreated | 2007-2-16 | lld:pubmed |
| pubmed-article:17237785 | pubmed:abstractText | Cytotoxic T lymphocytes and natural killer cells exert their cytotoxic activity through the polarized secretion of cytotoxic granules at the immunological synapse. Rab27a and hMunc13-4 are critical effectors of the exocytosis of cytotoxic granules. Here we show that the cytotoxic function of lymphocytes requires the cooperation of two types of organelles: the lysosomal cytotoxic granule and the endosomal 'exocytic vesicle'. Independently of Rab27a, hMunc13-4 mediated the assembly of Rab11(+) recycling and Rab27(+) late endosomal vesicles, constituting a pool of vesicles destined for regulated exocytosis. It also primed cytotoxic granule fusion, possibly through interaction with active Rab27a. Cytotoxic T lymphocyte-target cell recognition induced rapid polarization of both types of organelles, which coalesced near the cell-cell contact area. Our data provide insight into the regulation of the generation and release of cytotoxic granules by effector cytotoxic T lymphocytes and natural killer cells. | lld:pubmed |
| pubmed-article:17237785 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17237785 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237785 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17237785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17237785 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17237785 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17237785 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:FischerAlainA | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:RaposoGraçaG | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:FeldmannJérôm... | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:de Saint... | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:MénaschéGaëlG | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:RomaoMaryseM | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:KnapnougelPer... | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:MénagerMickaë... | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:HoChen-HsuanC... | lld:pubmed |
| pubmed-article:17237785 | pubmed:author | pubmed-author:GarfaMériemM | lld:pubmed |
| pubmed-article:17237785 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17237785 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:17237785 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17237785 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17237785 | pubmed:pagination | 257-67 | lld:pubmed |
| pubmed-article:17237785 | pubmed:dateRevised | 2007-11-8 | lld:pubmed |
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| pubmed-article:17237785 | pubmed:meshHeading | pubmed-meshheading:17237785... | lld:pubmed |
| pubmed-article:17237785 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17237785 | pubmed:articleTitle | Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4. | lld:pubmed |
| pubmed-article:17237785 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale Unité 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Paris F-75015 France. | lld:pubmed |
| pubmed-article:17237785 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17237785 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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