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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-3-7
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pubmed:abstractText |
The receptor for advanced glycation end products (RAGE) is associated with cancer progression in several human cancers. In this study, we examined the roles of RAGE in the angiogenesis of oral squamous cell carcinoma (OSCC). RAGE concentration was examined in 20 OSCC tumors by enzyme-linked immunosorbent assay (ELISA). The microvessel density (MVD) and lymph vessel density (LVD) were examined by immunostaining. Concentrations of vascular endothelial growth factor (VEGF) and VEGF-C were examined in tumor tissues by ELISA. Tumoral RAGE concentration was associated with higher tumor MVD (P = 0.0123) and tumor VEGF concentration (P = 0.0344), but not with LVD and VEGF-C concentration. Treatment with RAGE ligand, high-mobility group box (HMGB)-1 increased the secretion of VEGF but not that of VEGF-C in human OSCC cell lines, HSC-3 and HSC-4. The effect of HMGB-1 was abrogated by RAGE down-regulation by antisense S-oligodeoxynucleic acid. These results suggest that RAGE expression is closely associated to angiogenesis in OSCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/HMGB1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor C,
http://linkedlifedata.com/resource/pubmed/chemical/advanced glycosylation end-product...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0945-6317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
450
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-95
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pubmed:dateRevised |
2007-7-25
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pubmed:meshHeading |
pubmed-meshheading:17235565-Aged,
pubmed-meshheading:17235565-Aged, 80 and over,
pubmed-meshheading:17235565-Carcinoma, Squamous Cell,
pubmed-meshheading:17235565-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17235565-Female,
pubmed-meshheading:17235565-HMGB1 Protein,
pubmed-meshheading:17235565-Humans,
pubmed-meshheading:17235565-Lymphatic System,
pubmed-meshheading:17235565-Male,
pubmed-meshheading:17235565-Microcirculation,
pubmed-meshheading:17235565-Middle Aged,
pubmed-meshheading:17235565-Mouth Neoplasms,
pubmed-meshheading:17235565-Neoplasm Staging,
pubmed-meshheading:17235565-Neovascularization, Pathologic,
pubmed-meshheading:17235565-Receptors, Immunologic,
pubmed-meshheading:17235565-Recombinant Proteins,
pubmed-meshheading:17235565-Tumor Cells, Cultured,
pubmed-meshheading:17235565-Tumor Markers, Biological,
pubmed-meshheading:17235565-Vascular Endothelial Growth Factor A,
pubmed-meshheading:17235565-Vascular Endothelial Growth Factor C
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pubmed:year |
2007
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pubmed:articleTitle |
The expression of receptor for advanced glycation end products is associated with angiogenesis in human oral squamous cell carcinoma.
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pubmed:affiliation |
Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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