| pubmed-article:17235564 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C0153381 | lld:lifeskim |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C1439287 | lld:lifeskim |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C1420464 | lld:lifeskim |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17235564 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17235564 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17235564 | pubmed:dateCreated | 2007-3-7 | lld:pubmed |
| pubmed-article:17235564 | pubmed:abstractText | Aurora-B kinase is a chromosomal passenger protein and is essential for chromosome segregation and cytokinesis. Aurora-B overexpression in various cancer cells induces chromosomal number instability to produce multinuclearity and relates to metastasis. Here, we examined the expression of Aurora-B in oral squamous cell carcinoma (OSCC) to elucidate the relationship between Aurora-B expression and clinico-pathological findings by immunohistochemistry. Aurora-B expression was observed in normal oral squamous epithelia and OSCC cases, but the number of positive cells was significantly higher in OSCC than in normal squamous epithelium (p < 0.01). The labeling index of Aurora-B was significantly correlated with lymph node metastasis (p < 0.01) and histological grades of differentiation (p < 0.01). We also compared Aurora-B expression with Ki-67 expression and a positive correlation was found (p < 0.0001). Moreover, Aurora-B expression is significantly more frequent in multinuclear tumor cells than in total tumor cells. In summary, we found that Aurora-B expression was well correlated with cell proliferation, induction of multinuclear cells, histological differentiation, and metastasis in OSCC. These findings suggest that Aurora-B may be involved in tumor progression and that Aurora-B can be a new diagnostic and therapeutic target for OSCC. | lld:pubmed |
| pubmed-article:17235564 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17235564 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17235564 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17235564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17235564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17235564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17235564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17235564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17235564 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17235564 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17235564 | pubmed:issn | 0945-6317 | lld:pubmed |
| pubmed-article:17235564 | pubmed:author | pubmed-author:OgawaIkukoI | lld:pubmed |
| pubmed-article:17235564 | pubmed:author | pubmed-author:ShimamotoFumi... | lld:pubmed |
| pubmed-article:17235564 | pubmed:author | pubmed-author:KudoYasuseiY | lld:pubmed |
| pubmed-article:17235564 | pubmed:author | pubmed-author:TakataTakashi... | lld:pubmed |
| pubmed-article:17235564 | pubmed:author | pubmed-author:MiyauchiMutsu... | lld:pubmed |
| pubmed-article:17235564 | pubmed:author | pubmed-author:TatsukaMasaak... | lld:pubmed |
| pubmed-article:17235564 | pubmed:author | pubmed-author:SiriwardenaB... | lld:pubmed |
| pubmed-article:17235564 | pubmed:author | pubmed-author:QiGuangyingG | lld:pubmed |
| pubmed-article:17235564 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17235564 | pubmed:volume | 450 | lld:pubmed |
| pubmed-article:17235564 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17235564 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17235564 | pubmed:pagination | 297-302 | lld:pubmed |
| pubmed-article:17235564 | pubmed:dateRevised | 2011-7-11 | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:meshHeading | pubmed-meshheading:17235564... | lld:pubmed |
| pubmed-article:17235564 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17235564 | pubmed:articleTitle | Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. | lld:pubmed |
| pubmed-article:17235564 | pubmed:affiliation | Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. | lld:pubmed |
| pubmed-article:17235564 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:9212 | entrezgene:pubmed | pubmed-article:17235564 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17235564 | lld:entrezgene |
| lhgdn:association:16422 | lhgdn:found_in | pubmed-article:17235564 | lld:lhgdn |
