Source:http://linkedlifedata.com/resource/pubmed/id/17235564
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2007-3-7
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| pubmed:abstractText |
Aurora-B kinase is a chromosomal passenger protein and is essential for chromosome segregation and cytokinesis. Aurora-B overexpression in various cancer cells induces chromosomal number instability to produce multinuclearity and relates to metastasis. Here, we examined the expression of Aurora-B in oral squamous cell carcinoma (OSCC) to elucidate the relationship between Aurora-B expression and clinico-pathological findings by immunohistochemistry. Aurora-B expression was observed in normal oral squamous epithelia and OSCC cases, but the number of positive cells was significantly higher in OSCC than in normal squamous epithelium (p < 0.01). The labeling index of Aurora-B was significantly correlated with lymph node metastasis (p < 0.01) and histological grades of differentiation (p < 0.01). We also compared Aurora-B expression with Ki-67 expression and a positive correlation was found (p < 0.0001). Moreover, Aurora-B expression is significantly more frequent in multinuclear tumor cells than in total tumor cells. In summary, we found that Aurora-B expression was well correlated with cell proliferation, induction of multinuclear cells, histological differentiation, and metastasis in OSCC. These findings suggest that Aurora-B may be involved in tumor progression and that Aurora-B can be a new diagnostic and therapeutic target for OSCC.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0945-6317
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
450
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
297-302
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| pubmed:dateRevised |
2011-7-11
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| pubmed:meshHeading |
pubmed-meshheading:17235564-Adult,
pubmed-meshheading:17235564-Aged,
pubmed-meshheading:17235564-Aged, 80 and over,
pubmed-meshheading:17235564-Carcinoma, Squamous Cell,
pubmed-meshheading:17235564-Cell Count,
pubmed-meshheading:17235564-Cell Proliferation,
pubmed-meshheading:17235564-Epithelium,
pubmed-meshheading:17235564-Female,
pubmed-meshheading:17235564-Humans,
pubmed-meshheading:17235564-Immunoenzyme Techniques,
pubmed-meshheading:17235564-Ki-67 Antigen,
pubmed-meshheading:17235564-Lymph Nodes,
pubmed-meshheading:17235564-Male,
pubmed-meshheading:17235564-Middle Aged,
pubmed-meshheading:17235564-Mouth Neoplasms,
pubmed-meshheading:17235564-Neoplasm Metastasis,
pubmed-meshheading:17235564-Neoplasm Proteins,
pubmed-meshheading:17235564-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17235564-Tumor Markers, Biological
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer.
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| pubmed:affiliation |
Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
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| pubmed:publicationType |
Journal Article
|