Source:http://linkedlifedata.com/resource/pubmed/id/17235563
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2007-3-7
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| pubmed:abstractText |
Phosphatase of regenerating liver (PRL)-3, encoding a 22-kD low molecular weight tyrosine phosphatase, has been reported to be associated with metastasis of colorectal carcinoma. We assessed the levels of PRL-3 mRNA expression to know whether its up-regulation was involved in progression and metastasis of gastric carcinoma. Levels of PRL-3 expression in 94 human gastric adenocarcinomas and 54 matched lymph node metastases were detected by in situ hybridization and compared with clinicopathological characteristics including prognosis. High PRL-3 expression was detected in 36.2% of primary gastric carcinoma (with nodal metastasis, 55.6%; without nodal metastasis, 10%; P < 0.001) and in 74.1% of lymph node metastases. The incidence of high PRL-3 expression in lymph node metastasis was significantly higher than in primary tumors (P < 0.044). Moreover, high expression of PRL-3 was closely associated with tumor size, lymphatic invasion, venous invasion, extent of lymph node metastasis, and tumor stage. These results suggest that high PRL-3 expression may participate in the progression and metastasis of gastric carcinoma. PRL-3 might be a novel molecular marker for aggressive gastric cancer.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTP4A3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
|
| pubmed:issn |
0945-6317
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
450
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
303-10
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:17235563-Adenocarcinoma,
pubmed-meshheading:17235563-Adult,
pubmed-meshheading:17235563-Aged,
pubmed-meshheading:17235563-Aged, 80 and over,
pubmed-meshheading:17235563-Disease Progression,
pubmed-meshheading:17235563-Female,
pubmed-meshheading:17235563-Humans,
pubmed-meshheading:17235563-In Situ Hybridization,
pubmed-meshheading:17235563-Lymph Nodes,
pubmed-meshheading:17235563-Male,
pubmed-meshheading:17235563-Middle Aged,
pubmed-meshheading:17235563-Neoplasm Metastasis,
pubmed-meshheading:17235563-Neoplasm Proteins,
pubmed-meshheading:17235563-Neoplasm Staging,
pubmed-meshheading:17235563-Protein Tyrosine Phosphatases,
pubmed-meshheading:17235563-RNA, Messenger,
pubmed-meshheading:17235563-RNA, Neoplasm,
pubmed-meshheading:17235563-Stomach Neoplasms,
pubmed-meshheading:17235563-Survival Rate,
pubmed-meshheading:17235563-Tumor Markers, Biological,
pubmed-meshheading:17235563-Up-Regulation
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| pubmed:year |
2007
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| pubmed:articleTitle |
High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study.
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| pubmed:affiliation |
Division of Surgical Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|