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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5813
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pubmed:dateCreated |
2007-2-9
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pubmed:abstractText |
During development and tissue homeostasis, cells must integrate different signals. We investigated how cell behavior is controlled by the combined activity of transforming growth factor-beta (TGF-beta) and receptor tyrosine kinase (RTK) signaling, whose integration mechanism is unknown. We find that RTK/Ras/MAPK (mitogen-activated protein kinase) activity induces p53 N-terminal phosphorylation, enabling the interaction of p53 with the TGF-beta-activated Smads. This mechanism confines mesoderm specification in Xenopus embryos and promotes TGF-beta cytostasis in human cells. These data indicate a mechanism to allow extracellular cues to specify the TGF-beta gene-expression program.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
315
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
840-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17234915-Amino Acid Substitution,
pubmed-meshheading:17234915-Animals,
pubmed-meshheading:17234915-Casein Kinase Idelta,
pubmed-meshheading:17234915-Casein Kinase Iepsilon,
pubmed-meshheading:17234915-Cell Line, Tumor,
pubmed-meshheading:17234915-Cell Proliferation,
pubmed-meshheading:17234915-Embryo, Nonmammalian,
pubmed-meshheading:17234915-Embryonic Development,
pubmed-meshheading:17234915-Embryonic Induction,
pubmed-meshheading:17234915-Fibroblast Growth Factors,
pubmed-meshheading:17234915-Gene Expression Regulation, Developmental,
pubmed-meshheading:17234915-Humans,
pubmed-meshheading:17234915-Mesoderm,
pubmed-meshheading:17234915-Mitogen-Activated Protein Kinases,
pubmed-meshheading:17234915-Phosphorylation,
pubmed-meshheading:17234915-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:17234915-Signal Transduction,
pubmed-meshheading:17234915-Smad Proteins,
pubmed-meshheading:17234915-Transforming Growth Factor beta,
pubmed-meshheading:17234915-Tumor Suppressor Protein p53,
pubmed-meshheading:17234915-Xenopus,
pubmed-meshheading:17234915-ras Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.
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pubmed:affiliation |
Department of Medical Biotechnologies, Section of Histology and Embryology, University of Padua, Padua, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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