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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-3-7
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pubmed:abstractText |
NLRs (nucleotide oligomerisation domain [NOD] proteins containing a leucine-rich repeat) are cytosolic pattern recognition receptors. NOD1 senses diaminopimelic acid-containing peptidoglycan present in gram-negative bacteria, whereas NOD2 senses the muramyl dipeptide (MDP) present in most organisms. Bacteria are the most common cause of septic shock, which is characterized clinically by hypotension resistant to vasopressor agents. In animal models, gram-negative septic shock is mimicked by lipopolysaccharide (LPS), which signals through Toll-like receptor 4 (TLR4) and its adaptor MyD88. The role of NLRs in the pathophysiology of septic shock is not known.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylmuramyl-Alanyl-Isoglutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antithrombin III,
http://linkedlifedata.com/resource/pubmed/chemical/Card4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/FK 565,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nod1 Signaling Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/antithrombin III-protease complex,
http://linkedlifedata.com/resource/pubmed/chemical/romurtide
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1073-449X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
595-603
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pubmed:dateRevised |
2007-8-13
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pubmed:meshHeading |
pubmed-meshheading:17234906-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:17234906-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:17234906-Adjuvants, Immunologic,
pubmed-meshheading:17234906-Animals,
pubmed-meshheading:17234906-Antithrombin III,
pubmed-meshheading:17234906-Aorta,
pubmed-meshheading:17234906-Blood Pressure,
pubmed-meshheading:17234906-Cytokines,
pubmed-meshheading:17234906-Heart Rate,
pubmed-meshheading:17234906-Kidney,
pubmed-meshheading:17234906-Lipopolysaccharides,
pubmed-meshheading:17234906-Mice,
pubmed-meshheading:17234906-Multiple Organ Failure,
pubmed-meshheading:17234906-Muscle, Smooth, Vascular,
pubmed-meshheading:17234906-Muscle Contraction,
pubmed-meshheading:17234906-Myocytes, Smooth Muscle,
pubmed-meshheading:17234906-Neutrophils,
pubmed-meshheading:17234906-Nitric Oxide Synthase Type II,
pubmed-meshheading:17234906-Nod1 Signaling Adaptor Protein,
pubmed-meshheading:17234906-Oligopeptides,
pubmed-meshheading:17234906-Pancreas,
pubmed-meshheading:17234906-Peptide Hydrolases,
pubmed-meshheading:17234906-Shock
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pubmed:year |
2007
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pubmed:articleTitle |
Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo.
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pubmed:affiliation |
Department of Critical Care, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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