Linked Life Data

17234342

Source:http://linkedlifedata.com/resource/pubmed/id/17234342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-3-12
pubmed:abstractText
Though orofacial movements are fundamental motor patterns that are known to be regulated critically by D1-like dopamine receptors, these processes remain poorly understood. This uncertainty is heightened by evidence for putative D1-like receptors that are linked not only to adenylyl cyclase (AC) but also to phospholipase C (PLC). Using a new method, we have characterised four topographies of orofacial movement in the mouse using the novel D1-like agonist SKF 83822, which stimulates AC but not PLC. These were compared with responses to SKF 83959, which stimulates PLC but not AC. Also, effects were characterised using the D1-like antagonist SCH 23390 and the D2-like antagonist YM 09151-2. SKF 83822 induced vertical jaw movements with incisor chattering but inhibited horizontal jaw movements; there was little effect on tongue protrusions. Vertical jaw movements induced by SKF 83822 were inhibited by SCH 23390 but uninfluenced by YM 09151-2, while YM 09151-2 released horizontal jaw movements; thus, D1-like agonist-induced, AC-mediated vertical jaw movements constitute a 'pure' D1-like-dependent process that does not involve D1-like:D2-like interactions, while horizontal jaw movements involve oppositional interactions. Orofacial movements in mice appear to consist of at least four phenomenologically dissociable topographies that are mechanistically distinct. They are regulated differentially by AC- and/or PLC-dependent processes and these processes involve distinct D1-like:D2-like interactions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
415
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-10
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:17234342-Adenylate Cyclase, pubmed-meshheading:17234342-Animals, pubmed-meshheading:17234342-Benzazepines, pubmed-meshheading:17234342-Brain Mapping, pubmed-meshheading:17234342-Dopamine, pubmed-meshheading:17234342-Dopamine Agonists, pubmed-meshheading:17234342-Dopamine Antagonists, pubmed-meshheading:17234342-Dose-Response Relationship, Drug, pubmed-meshheading:17234342-Efferent Pathways, pubmed-meshheading:17234342-Facial Muscles, pubmed-meshheading:17234342-Male, pubmed-meshheading:17234342-Masticatory Muscles, pubmed-meshheading:17234342-Mice, pubmed-meshheading:17234342-Mice, Inbred C57BL, pubmed-meshheading:17234342-Motor Cortex, pubmed-meshheading:17234342-Movement, pubmed-meshheading:17234342-Nerve Net, pubmed-meshheading:17234342-Receptors, Dopamine D1, pubmed-meshheading:17234342-Receptors, Dopamine D2, pubmed-meshheading:17234342-Synaptic Transmission, pubmed-meshheading:17234342-Type C Phospholipases
pubmed:year
2007
pubmed:articleTitle
Differential involvement of cyclase- versus non-cyclase-coupled D1-like dopamine receptors in orofacial movement topography in mice: studies with SKF 83822.
pubmed:affiliation
Department of Pharmacology and Dental Research Centre, Nihon University School of Dentistry, Tokyo 101-8310, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't