Source:http://linkedlifedata.com/resource/pubmed/id/17234123
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
31
|
| pubmed:dateCreated |
2007-1-19
|
| pubmed:abstractText |
Multiple resistance to cytotoxic cancer drugs dramatically reduces the effectiveness of these drugs on many occasions. ABC (ATP-binding cassette) transporters pump out cytotoxic cancer drugs from cells, preventing them from reaching therapeutic levels. However, co-administration ABC transporter inhibitors with cytotoxic cancer drugs did not effectively improve the treatment outcome. The mechanisms and remedies are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1944-7930
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
18-23
|
| pubmed:meshHeading |
pubmed-meshheading:17234123-ATP-Binding Cassette Transporters,
pubmed-meshheading:17234123-Animals,
pubmed-meshheading:17234123-Antineoplastic Agents,
pubmed-meshheading:17234123-Drug Resistance, Neoplasm,
pubmed-meshheading:17234123-Humans,
pubmed-meshheading:17234123-Models, Biological,
pubmed-meshheading:17234123-Neoplasms
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Defeating drug resistance in cancer.
|
| pubmed:affiliation |
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
|
| pubmed:publicationType |
Journal Article
|