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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
|
pubmed:dateCreated |
1992-3-12
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pubmed:abstractText |
The experiments on Wistar rats showed that microinjection of C-terminal fragment of substance P-CP5-11 (1 microgram) into one of the antinociceptive system structure--dorsal raphe nucleus, caused a prolonged (24 hours of observation) analgetic effect by the hot plate test. Neuronal activity of dorsal raphe nucleus simultaneously enhanced. The CP5-11 antinociceptive activity was higher than the CP1-11 one. The conclusion is that CP1-11 and in particular its C-terminal fragment CP5-11 play a role in activation of antinociceptive system.
|
pubmed:language |
rus
|
pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0365-9615
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
112
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
578-80
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pubmed:dateRevised |
2008-10-8
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pubmed:meshHeading |
pubmed-meshheading:1723329-Analgesics,
pubmed-meshheading:1723329-Animals,
pubmed-meshheading:1723329-Male,
pubmed-meshheading:1723329-Neurons,
pubmed-meshheading:1723329-Pain Measurement,
pubmed-meshheading:1723329-Peptide Fragments,
pubmed-meshheading:1723329-Raphe Nuclei,
pubmed-meshheading:1723329-Rats,
pubmed-meshheading:1723329-Rats, Inbred Strains,
pubmed-meshheading:1723329-Substance P
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pubmed:year |
1991
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pubmed:articleTitle |
[Effects of C-terminal fragment of substance P-CP 5-11 on the activity of neurons of the dorsal raphe nucleus].
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|