rdf:type |
|
lifeskim:mentions |
umls-concept:C0004475,
umls-concept:C0017262,
umls-concept:C0018850,
umls-concept:C0042542,
umls-concept:C0178539,
umls-concept:C0185117,
umls-concept:C0205164,
umls-concept:C0205263,
umls-concept:C0205725,
umls-concept:C0206355,
umls-concept:C2911684
|
pubmed:issue |
4
|
pubmed:dateCreated |
1992-3-3
|
pubmed:abstractText |
Human cytomegalovirus can support an abortive infection in Vero cells and only some immediate early events are expressed in a low proportion of the cell population. It has been shown that cellular factors partially remove blocks in cells abortively or latently infected by HCMV, whereas 5-azacytidine is known to act on gene expression and cell differentiation. In this work we present evidence that the treatment of HCMV infected Vero cells with 5-azacytidine induces the expression of the major immediate early protein (68K) of Human cytomegalovirus by enhancing a 72K cellular heat shock protein.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0391-5352
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
287-94
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1723134-Animals,
pubmed-meshheading:1723134-Antigens, Viral,
pubmed-meshheading:1723134-Azacitidine,
pubmed-meshheading:1723134-Cytomegalovirus,
pubmed-meshheading:1723134-Fluorescent Antibody Technique,
pubmed-meshheading:1723134-Gene Expression Regulation, Viral,
pubmed-meshheading:1723134-Heat-Shock Proteins,
pubmed-meshheading:1723134-Humans,
pubmed-meshheading:1723134-Immediate-Early Proteins,
pubmed-meshheading:1723134-Immunoblotting,
pubmed-meshheading:1723134-Vero Cells
|
pubmed:year |
1991
|
pubmed:articleTitle |
5-Azacytidine induction of a cellular heat shock protein and expression of the major immediate early protein of human cytomegalovirus in Vero cells.
|
pubmed:affiliation |
Istituto di Microbiologia, Università di Bologna, Italy.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|