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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-3-4
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pubmed:abstractText |
The changes in relevant haemostatic parameters during the course of ten orthotopic liver transplantation were studied when aprotinin was given intra-operatively. Increases of tissue-type (P = 0.008) and urokinase-type (P = 0.009) plasminogen activators during the anhepatic phase could be correlated with hyperfibrinolysis. Thrombin-antithrombin III complexes (TAT) increased after revascularization of the liver graft (P = 0.003). Parallel studies in the perfusate showed that TAT concentrations were 350% and protease inhibitor activities (antithrombin III, protein C) only 52% of the systemic circulation before reperfusion, suggesting that thrombin activation together with protease inhibitor consumption occurs during graft liver reperfusion. The relatively smaller increases in profibrinolytic parameters and a lower blood loss when compared with other groups may be explained by aprotinin administration in our patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0957-5235
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1723011-Antithrombin III,
pubmed-meshheading:1723011-Aprotinin,
pubmed-meshheading:1723011-Blood Coagulation Disorders,
pubmed-meshheading:1723011-Blood Loss, Surgical,
pubmed-meshheading:1723011-Fibrinogen,
pubmed-meshheading:1723011-Fibrinolysis,
pubmed-meshheading:1723011-Humans,
pubmed-meshheading:1723011-Intraoperative Care,
pubmed-meshheading:1723011-Liver Transplantation,
pubmed-meshheading:1723011-Peptide Hydrolases,
pubmed-meshheading:1723011-Perfusion,
pubmed-meshheading:1723011-Plasminogen Activators,
pubmed-meshheading:1723011-Protein C,
pubmed-meshheading:1723011-Reperfusion
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pubmed:year |
1991
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pubmed:articleTitle |
Coagulation changes and the influence of the early perfusate in the course of orthotopic liver transplantation (OLT) when aprotinin is used intra-operatively.
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pubmed:affiliation |
Department of Internal Medicine, Universitätsklinikum Rudolf Virchow, Berlin, Germany.
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pubmed:publicationType |
Journal Article
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