| pubmed-article:17229879 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17229879 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17229879 | lifeskim:mentions | umls-concept:C0025474 | lld:lifeskim |
| pubmed-article:17229879 | lifeskim:mentions | umls-concept:C0042401 | lld:lifeskim |
| pubmed-article:17229879 | lifeskim:mentions | umls-concept:C0007009 | lld:lifeskim |
| pubmed-article:17229879 | lifeskim:mentions | umls-concept:C0288250 | lld:lifeskim |
| pubmed-article:17229879 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17229879 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:17229879 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17229879 | pubmed:dateCreated | 2007-3-19 | lld:pubmed |
| pubmed-article:17229879 | pubmed:abstractText | Large-conductance calcium-activated potassium channels (BK(Ca)s) are important regulators of arterial tone and represent a mediator of the endogenous vasodilator carbon monoxide (CO). Because an up-regulation of the heme oxygenase (HO)/CO system has been associated with mesenteric vasodilatation of cirrhosis, we analyzed the interactions of BK(Ca) and of HO/CO in the endothelium-dependent dilatation of mesenteric arteries in ascitic cirrhotic rats. In pressurized mesenteric arteries (diameter, 170-350 microm) of ascitic cirrhotic rats, we evaluated the effect of inhibition of BK(Ca), HO, and guanylyl-cyclase on dilatation induced by acetylcholine and by exogenous CO; and HO-1 and BK(Ca) subunit protein expression. Inhibition of HO and of BK(Ca) reduced acetylcholine-induced vasodilatation more in cirrhotic rats than in control rats, whereas inhibition of guanylyl-cyclase had a similar effect in the two groups. CO was more effective in cirrhotic rats than in control rats, and the effect was hindered by BK(Ca) inhibition. The expression of HO-1 and of BK(Ca) alpha-subunit was higher in mesenteric arteries of cirrhotic rats compared with that of control animals, whereas the expression of the BK(Ca) beta1-subunit was lower. In conclusion, an overexpression of BK(Ca) alpha-subunits, possibly due to HO up-regulation with increased CO production, participates in the endothelium-dependent alterations and mesenteric arterial vasodilatation of ascitic cirrhotic rats. | lld:pubmed |
| pubmed-article:17229879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17229879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17229879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17229879 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17229879 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:AngeliPaoloP | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:MerkelCarloC | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:MotterliniRob... | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:BolognesiMass... | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:SacerdotiDavi... | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:GattaAngeloA | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:ZampieriFranc... | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:QuartaSantina... | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:17229879 | pubmed:author | pubmed-author:PivaAnnaA | lld:pubmed |
| pubmed-article:17229879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17229879 | pubmed:volume | 321 | lld:pubmed |
| pubmed-article:17229879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17229879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17229879 | pubmed:pagination | 187-94 | lld:pubmed |
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| pubmed-article:17229879 | pubmed:meshHeading | pubmed-meshheading:17229879... | lld:pubmed |
| pubmed-article:17229879 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17229879 | pubmed:articleTitle | Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats. | lld:pubmed |
| pubmed-article:17229879 | pubmed:affiliation | Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy. massimo.bolognesi@unipd.it | lld:pubmed |
| pubmed-article:17229879 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17229879 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:17229879 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17229879 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17229879 | lld:pubmed |
