Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-3-19
pubmed:abstractText
Large-conductance calcium-activated potassium channels (BK(Ca)s) are important regulators of arterial tone and represent a mediator of the endogenous vasodilator carbon monoxide (CO). Because an up-regulation of the heme oxygenase (HO)/CO system has been associated with mesenteric vasodilatation of cirrhosis, we analyzed the interactions of BK(Ca) and of HO/CO in the endothelium-dependent dilatation of mesenteric arteries in ascitic cirrhotic rats. In pressurized mesenteric arteries (diameter, 170-350 microm) of ascitic cirrhotic rats, we evaluated the effect of inhibition of BK(Ca), HO, and guanylyl-cyclase on dilatation induced by acetylcholine and by exogenous CO; and HO-1 and BK(Ca) subunit protein expression. Inhibition of HO and of BK(Ca) reduced acetylcholine-induced vasodilatation more in cirrhotic rats than in control rats, whereas inhibition of guanylyl-cyclase had a similar effect in the two groups. CO was more effective in cirrhotic rats than in control rats, and the effect was hindered by BK(Ca) inhibition. The expression of HO-1 and of BK(Ca) alpha-subunit was higher in mesenteric arteries of cirrhotic rats compared with that of control animals, whereas the expression of the BK(Ca) beta1-subunit was lower. In conclusion, an overexpression of BK(Ca) alpha-subunits, possibly due to HO up-regulation with increased CO production, participates in the endothelium-dependent alterations and mesenteric arterial vasodilatation of ascitic cirrhotic rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine, http://linkedlifedata.com/resource/pubmed/chemical/Carbon Monoxide, http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase, http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing), http://linkedlifedata.com/resource/pubmed/chemical/Large-Conductance..., http://linkedlifedata.com/resource/pubmed/chemical/Mesoporphyrins, http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine, http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents, http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents, http://linkedlifedata.com/resource/pubmed/chemical/chromium mesoporphyrin, http://linkedlifedata.com/resource/pubmed/chemical/tricarbonylchloro(glycinato)rutheniu...
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
321
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-94
pubmed:meshHeading
pubmed-meshheading:17229879-Acetylcholine, pubmed-meshheading:17229879-Animals, pubmed-meshheading:17229879-Blood Pressure, pubmed-meshheading:17229879-Carbon Monoxide, pubmed-meshheading:17229879-Carbon Tetrachloride Poisoning, pubmed-meshheading:17229879-Endothelium, Vascular, pubmed-meshheading:17229879-Guanylate Cyclase, pubmed-meshheading:17229879-Heart Rate, pubmed-meshheading:17229879-Heme Oxygenase (Decyclizing), pubmed-meshheading:17229879-Large-Conductance Calcium-Activated Potassium Channels, pubmed-meshheading:17229879-Liver Cirrhosis, pubmed-meshheading:17229879-Male, pubmed-meshheading:17229879-Mesenteric Arteries, pubmed-meshheading:17229879-Mesoporphyrins, pubmed-meshheading:17229879-Organometallic Compounds, pubmed-meshheading:17229879-Phenylephrine, pubmed-meshheading:17229879-Rats, pubmed-meshheading:17229879-Rats, Wistar, pubmed-meshheading:17229879-Signal Transduction, pubmed-meshheading:17229879-Splanchnic Circulation, pubmed-meshheading:17229879-Vascular Resistance, pubmed-meshheading:17229879-Vasoconstrictor Agents, pubmed-meshheading:17229879-Vasodilation, pubmed-meshheading:17229879-Vasodilator Agents
pubmed:year
2007
pubmed:articleTitle
Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats.
pubmed:affiliation
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy. massimo.bolognesi@unipd.it
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't