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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0021311,
umls-concept:C0023779,
umls-concept:C0038411,
umls-concept:C0042196,
umls-concept:C0442118,
umls-concept:C0444669,
umls-concept:C0449432,
umls-concept:C0524527,
umls-concept:C0599934,
umls-concept:C0700271,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1545588,
umls-concept:C1548799,
umls-concept:C1554184,
umls-concept:C1705248,
umls-concept:C2349975
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pubmed:issue |
10
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pubmed:dateCreated |
2007-2-5
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pubmed:abstractText |
We investigated the efficacy of a synthetic Streptococcus pyogenes vaccine targeting two virulence factors using the Lipid Core Peptide (LCP) delivery system. BALB/c mice were immunised intranasally with LCPs containing peptides encompassing T-cell and B-cell epitopes of the conserved C-repeat region of the M protein (J8) or the fibronectin-binding repeats region (FNBR) of SfbI, or a combination formulation containing peptides representing both antigens. LCPs were co-administered with the TLR2/6 agonist MALP-2 as mucosal adjuvant. Humoral and cellular immune responses stimulated at systemic and mucosal levels were strongest in mice immunised with the dual antigen formulation. Mice were completely protected following a respiratory challenge with a lethal dose of a heterologous S. pyogenes strain, whereas there was 70% and 90% survival in mice immunised with LCP-J8 and LCP-FNBR, respectively. This is the first report demonstrating the elicitation of better protective immunity by a dual antigen component S. pyogenes vaccine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adhesins, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Outer Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, B-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Streptococcal Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/fibronectin-binding proteins...,
http://linkedlifedata.com/resource/pubmed/chemical/macrophage stimulatory lipopeptide 2,
http://linkedlifedata.com/resource/pubmed/chemical/streptococcal M protein
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1789-97
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pubmed:dateRevised |
2010-10-19
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pubmed:meshHeading |
pubmed-meshheading:17229503-Adhesins, Bacterial,
pubmed-meshheading:17229503-Adjuvants, Immunologic,
pubmed-meshheading:17229503-Administration, Intranasal,
pubmed-meshheading:17229503-Animals,
pubmed-meshheading:17229503-Antibodies, Bacterial,
pubmed-meshheading:17229503-Antigens, Bacterial,
pubmed-meshheading:17229503-Bacterial Outer Membrane Proteins,
pubmed-meshheading:17229503-Carrier Proteins,
pubmed-meshheading:17229503-Disease Models, Animal,
pubmed-meshheading:17229503-Epitopes, B-Lymphocyte,
pubmed-meshheading:17229503-Epitopes, T-Lymphocyte,
pubmed-meshheading:17229503-Leukocytes, Mononuclear,
pubmed-meshheading:17229503-Lipopeptides,
pubmed-meshheading:17229503-Mice,
pubmed-meshheading:17229503-Mice, Inbred BALB C,
pubmed-meshheading:17229503-Oligopeptides,
pubmed-meshheading:17229503-Streptococcal Infections,
pubmed-meshheading:17229503-Streptococcal Vaccines,
pubmed-meshheading:17229503-Streptococcus pyogenes,
pubmed-meshheading:17229503-Vaccines, Subunit,
pubmed-meshheading:17229503-Vaccines, Synthetic
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pubmed:year |
2007
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pubmed:articleTitle |
Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation.
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pubmed:affiliation |
Cooperative Research Centre for Vaccine Technology, Division of Infectious Diseases and Immunology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Colleen.OliveO@qimir.edu.au
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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