Linked Life Data

17228866

Source:http://linkedlifedata.com/resource/pubmed/id/17228866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-1-18
pubmed:abstractText
Plant polyphenols exhibit a variety of potentially useful biochemical properties in vitro, but their evaluation and clinical exploitation in vivo is hampered by their limited bioavailability. Precursors exhibiting resistance to phase II metabolism during absorption are therefore desirable. We report here the synthesis as well as stability and solubility studies of several ester derivatives of quercetin (3,3',4',5,7-pentahydroxy flavone), most of which comprise an aminoacyl group. To model transepithelial absorption, we tested transport across supported tight monolayers of MDCK-1, MDCK-2, and Caco-2 cells. Quercetin itself was extensively conjugated by all three types of cells. A few of our precursors did not cross the monolayers, but others did, undergoing partial deacylation. No phase II conjugation was observed during transport of these compounds across MDCK or some Caco-2 clones. With other Caco-2 lines complete deacylation occurred, followed by metabolism of quercetin. Since elimination of residual acyl groups is expected to take place in vivo, ester derivatives of polyphenols may constitute a useful method to increase systemic aglycone concentrations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-53
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Ester-based precursors to increase the bioavailability of quercetin.
pubmed:affiliation
Department of Biomedical Sciences, University of Padova, Padova, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't